P. Darbre

Publications176
h-index44
Citations6,653
Highly Influential Citations217
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Concentrations of parabens in human breast tumours
Parabens are used as preservatives in many thousands of cosmetic, food and pharmaceutical products to which the human population is exposed. Although recent reports of the oestrogenic properties of… Expand
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  • 27
  • PDF
Paraben esters: review of recent studies of endocrine toxicity, absorption, esterase and human exposure, and discussion of potential human health risks
This toxicology update reviews research over the past four years since publication in 2004 of the first measurement of intact esters of p‐hydroxybenzoic acid (parabens) in human breast cancer… Expand
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  • PDF
Oestrogenic and androgenic activity of triclosan in breast cancer cells
As a consequence of its widespread use as an antimicrobial agent in consumer goods, triclosan has become distributed ubiquitously across the ecosystem, and recent reports that it can cause endocrine… Expand
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Measurement of paraben concentrations in human breast tissue at serial locations across the breast from axilla to sternum
The concentrations of five esters of p‐hydroxybenzoic acid (parabens) were measured using HPLC‐MS/MS at four serial locations across the human breast from axilla to sternum using human breast tissue… Expand
  • 141
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Effect of estradiol on human breast cancer cells in culture.
Conditions are described for growing and maintaining the estradiol sensitivity of the human breast cancer cell line ZR-75-1 both in monolayer and suspension cultures. Either newborn calf or fetal… Expand
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Oestrogenic activity of isobutylparaben in vitro and in vivo
The alkyl esters of p‐hydroxybenzoic acid (parabens) are used widely as preservatives in foods, pharmaceuticals and cosmetics to which the human population is exposed. Recent studies have reported… Expand
  • 150
  • 9
Environmental oestrogens, cosmetics and breast cancer.
  • P. Darbre
  • Medicine
  • Best practice & research. Clinical endocrinology…
  • 1 March 2006
The established role of oestrogen in the development and progression of breast cancer raises questions concerning a potential contribution from the many chemicals in the environment which can enter… Expand
  • 191
  • 7
  • PDF
Combinations of parabens at concentrations measured in human breast tissue can increase proliferation of MCF‐7 human breast cancer cells
The alkyl esters of p‐hydroxybenzoic acid (parabens), which are used as preservatives in consumer products, possess oestrogenic activity and have been measured in human breast tissue. This has raised… Expand
  • 88
  • 7
Oestrogenic activity of benzylparaben
Previous work has demonstrated that the alkyl esters of p‐hydroxybenzoic acid (parabens) possess oestrogenic activity, which increases with length of alkyl chain from methylparaben to n‐butylparaben… Expand
  • 137
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Metalloestrogens: an emerging class of inorganic xenoestrogens with potential to add to the oestrogenic burden of the human breast
  • P. Darbre
  • Chemistry, Medicine
  • Journal of applied toxicology : JAT
  • 1 May 2006
Many compounds in the environment have been shown capable of binding to cellular oestrogen receptors and then mimicking the actions of physiological oestrogens. The widespread origin and diversity in… Expand
  • 221
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