Concentrations of parabens in human breast tumours
- P. Darbre, A. Aljarrah, W. R. Miller, N. Coldham, M. Sauer, G. S. Pope
- Medicine, Environmental ScienceJournal of Applied Toxicology
- 2004
Initial studies reported here show that parabens can be extracted from human breast tissue and detected by thin‐layer chromatography and this should open the way technically for more detailed information to be obtained on body burdens of paraben and in particular whether body burdens are different in cancer from those in normal tissues.
Paraben esters: review of recent studies of endocrine toxicity, absorption, esterase and human exposure, and discussion of potential human health risks
There is a need to carry out detailed evaluation of the potential for parabens, together with other oestrogenic and genotoxic co‐formulants of bodycare cosmetics, to increase female breast cancer incidence, to interfere with male reproductive functions and to influence development of malignant melanoma.
Measurement of paraben concentrations in human breast tissue at serial locations across the breast from axilla to sternum
- L. Barr, G. Metaxas, C. Harbach, L. Savoy, P. Darbre
- MedicineJournal of Applied Toxicology
- 1 March 2012
The concentrations of five esters of p‐hydroxybenzoic acid (parabens) were measured using HPLC‐MS/MS at four serial locations across the human breast from axilla to sternum using human breast tissue…
Comparative study of oestrogenic properties of eight phytoestrogens in MCF7 human breast cancer cells
- A. Matsumura, A. Ghosh, G. S. Pope, P. Darbre
- BiologyJournal of Steroid Biochemistry and Molecular…
- 1 April 2005
Effect of estradiol on human breast cancer cells in culture.
Estradiol markedly increased the ability of the cells to grow both in suspension and semisolid Methocel cultures, and a major loss of estradiol response was found if the cells were grown for 7 to 14 days in the absence ofEstradiol.
Oestrogenic activity of isobutylparaben in vitro and in vivo
- P. Darbre, J. Byford, L. Shaw, R. Horton, G. S. Pope, M. Sauer
- Biology, ChemistryJournal of Applied Toxicology
- 1 July 2002
Results here show that branching of the alkyl chain to isobutylparaben increases oestrogenic activity beyond that of the equivalent length linear alkyL chain in n‐butyl paraben.
Endocrine Disruptors and Obesity
- P. Darbre
- BiologyCurrent Obesity Reports
- 15 February 2017
In summarising the actions of obesogens, it is noteworthy that as their structures are mainly lipophilic, their ability to increase fat deposition has the added consequence of increasing the capacity for their own retention, which has the potential for a vicious spiral of increasing obesity.
Metalloestrogens: an emerging class of inorganic xenoestrogens with potential to add to the oestrogenic burden of the human breast
- P. Darbre
- Chemistry, MedicineJournal of Applied Toxicology
- 1 May 2006
This report highlights studies which show metalloestrogens to include aluminium, antimony, arsenite, barium, cadmium, chromium (Cr(II)), cobalt, copper, lead, mercury, nickel, selenite, tin and vanadate and the potential for these metal ions to add to the burden of aberrant oestrogen signalling within the human breast is discussed.
Environmental oestrogens, cosmetics and breast cancer.
- P. Darbre
- Medicine, BiologyBest practice & research. Clinical endocrinology…
- 1 March 2006
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