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Mesenchymal stem cell therapy for heart disease.
Paracrine Mechanisms of Mesenchymal Stem Cells in Tissue Repair.
It is proposed that the functional benefits observed after MSC transplantation in experimental models of tissue injury might be related to the secretion of soluble factors acting in a paracrine fashion, and this hypothesis is supported by pre-clinical studies demonstrating equal or even improved organ function upon infusion of MSC-derived conditioned medium (MSC-CM) compared with M SC transplantation.
Conditioned Medium From Human Amniotic Mesenchymal Stromal Cells Limits Infarct Size and Enhances Angiogenesis
The results strongly support the concept that the administration of hAMC‐CM favors the repair process after acute myocardial infarction.
Combination of miRNA499 and miRNA133 Exerts a Synergic Effect on Cardiac Differentiation
The results show that the areas spontaneously contracting possess electrophysiological and pharmacological characteristics compatible with true cardiac excitation‐contraction coupling, and the translational relevance was reinforced by the demonstration that the over‐expression of miRNA499 and miRNA133 was also able to induce the differentiation of human mesenchymal stromal cells toward the cardiac lineage.
Testing the Paracrine Properties of Human Mesenchymal Stem Cells Using Conditioned Medium.
In this chapter, a straightforward method to prepare MSC-derived CM is described and some in vitro assays useful for testing the cytoprotective, angiogenic, and regenerative activity of CM are summarized.
Overexpression of growth factors to improve cardiac differentiation of human mesenchymal stem cells derived from the amniotic membrane
It is shown that the overexpression of either IGF-I, or BMP2, or TGFβ1 or B MP2, significantly increases the differentiation efficiency of A-MSC into CMC, which seems to be the most relevant cardiac differentiation triggers.
Abstract 16777: Identification of Cardioprotective Factors Produced by Fetal Mesenchymal Stem Cells Through a Combined Transcriptomic and Proteomic Approach
Abstract 16578: Donor Age Negatively Influences Cytoprotective but Not Proangiogenic Paracrine Properties of Human Mesenchymal Stem Cells
Donor Age Impairs the Capacity of Human Mesenchymal Stromal Cells to Repair Cardiac and Renal Damage