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Myosin X regulates netrin receptors and functions in axonal path-finding
Netrins regulate axon path-finding during development, but the underlying mechanisms are not well understood. Here, we provide evidence for the involvement of the unconventional myosin X (Myo X) inExpand
Activity-dependent transcription regulation of PSD-95 by neuregulin-1 and Eos
Neuregulin-1 (Nrg-1) contains an intracellular domain (Nrg-ICD) that translocates into the nucleus, where it may regulate gene expression upon neuronal depolarization. However, the identity of itsExpand
Modulation of TLR Signaling by Multiple MyD88-Interacting Partners Including Leucine-Rich Repeat Fli-I-Interacting Proteins1
Emerging evidences suggest TLR-mediated signaling is tightly regulated by a specific chain of intracellular protein-protein interactions, some of which are yet to be identified. Previously weExpand
Erbin Inhibits Transforming Growth Factor β Signaling through a Novel Smad-Interacting Domain
ABSTRACT Smad proteins are critical intracellular signaling mediators for the transforming growth factor β (TGFβ) superfamily. Here, we report that Erbin (for “ErbB2/Her2-interacting protein”), whichExpand
Erbin Inhibits RAF Activation by Disrupting the Sur-8-Ras-Raf Complex*
Erbin is a member of the LAP (leucine-rich repeat (LRR) and PDZ domain) family. It inhibits Ras-mediated activation of ERK in response to growth factors. In this study, we investigated the mechanismsExpand
Erbin regulates NRG1 signaling and myelination
  • Y. Tao, P. Dai, +4 authors L. Mei
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 9 June 2009
Neuregulin 1 (NRG1) plays a critical role in myelination. However, little is known about regulatory mechanisms of NRG1 signaling. We show here that Erbin, a protein that contains leucine-rich repeatsExpand
Protein phosphatase 2A catalytic subunit α plays a MyD88-dependent, central role in the gene-specific regulation of endotoxin tolerance.
MyD88, the intracellular adaptor of most TLRs, mediates either proinflammatory or immunosuppressive signaling that contributes to chronic inflammation-associated diseases. Although gene-specificExpand
Differential regulation of myosin X movements by its cargos, DCC and neogenin
Myosin X (Myo X), also known as MYO10, is an unconventional actin-based motor protein that plays an important role in filopodium formation. Its intra-filopodia movement, an event tightly associatedExpand
Regulation of ID4 In Vivo for Efficient Magnetothermal Therapy of Breast Cancer
Magnetic nanoparticles (MNPs) mediated magnetothermal therapy (MTT) has been proven as a promising modality for tumor treatment. However, the low therapeutic efficacy presents a major obstacle to itsExpand