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A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death
A novel PERK‐dependent subroutine for the early and simultaneous emission of two critical DAMPs following ROS‐mediated ER stress is unraveled.
Liposomes for photodynamic therapy.
This review covers the different liposomal strategies that are available to target photosensitizers to tumor tissue and suggests that liposomes with a specifically modified design, i.e. long-circulating and especially actively targeting liposome, stand a better chance in becoming truly tumoritropic carriers of photosensiter molecules.
Evaluation of 14 Organic Solvents and Carriers for Screening Applications in Zebrafish Embryos and Larvae
- Jan Maes, L. Verlooy, O. E. Buenafe, P. D. de Witte, Camila V. Esguerra, A. Crawford
- Biology, MedicinePloS one
- 17 October 2012
This study resulted in the identification of polyethylene glycol (PEG400), propylene glycol, and methanol as solvents that were relatively well-tolerated over a range of developmental stages and showed that acetone was well-Tolerated by embryos but not by larvae, and 1% cyclodextrin (HPBCD), indicating the utility of this carrier for compound screening in zebrafish.
Cytotoxicity of some medicinal plant extracts used in Tanzanian traditional medicine.
The results indicate that there is no correlation between the reported use of these plants and their cytotoxic activity obtained in this study, however, plants that have shown pronounced cytot toxic activity will be evaluated further for the possible isolation of active antitumor compounds.
The Activation of the c-Jun N-terminal Kinase and p38 Mitogen-activated Protein Kinase Signaling Pathways Protects HeLa Cells from Apoptosis Following Photodynamic Therapy with Hypericin*
- Z. Assefa, A. Vantieghem, +5 authors P. Agostinis
- Biology, MedicineThe Journal of Biological Chemistry
- 26 March 1999
Observations indicate that the JNK1 and p38 MAPK pathways play an important role in cellular resistance against PDT-induced apoptosis with hypericin.
Validation of the Zebrafish Pentylenetetrazol Seizure Model: Locomotor versus Electrographic Responses to Antiepileptic Drugs
The results underscore the validity of using the zebrafish larval locomotor assay as a rapid first-pass screening tool in assessing the anticonvulsant and/or proconvulsant activity of compounds, but also highlight the importance of performing adequate validation when using in vivo models.
Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death
The main molecular, immunological, preclinical, and clinical aspects of ICD are summarized and tabulate in an attempt to capture the essence of this phenomenon, and identify future challenges for this rapidly expanding field of investigation.
Structure-Based Identification of OATP1B1/3 Inhibitors
- T. de Bruyn, G. V. van Westen, +4 authors P. Annaert
- Biology, MedicineMolecular Pharmacology
- 1 June 2013
A proteochemometrics-based in silico model was developed, which predicted OATP1B inhibitors in the test group with high specificity (86%) and sensitivity (78%) and was prospectively verified with a set of 54 compounds not included in the original dataset.
Targeting of the photocytotoxic compound AlPcS4 to hela cells by transferrin conjugated peg‐liposomes
- A. Gijsens, A. Derycke, +4 authors P. D. de Witte
- Chemistry, MedicineInternational journal of cancer
- 1 September 2002
The photodynamic activity of the Tf‐Lip‐AlPcS4 conjugate on HeLa cells is much more potent than free AlP cS4 as a result of selective transferrin receptor mediated uptake, and the accumulation and photocytotoxicity profile of the different photo‐active compounds.
The antiplasmodial activity of isolates from Ajuga remota.
- K. Kuria, H. Chepkwony, +10 authors G. Laekeman
- Biology, MedicineJournal of natural products
- 1 May 2002
Both ajugarin-1 and ergosterol-5,8-endoperoxide did not exhibit cytotoxicity against A431 (skin carcinoma) cell line, but 8-O-acetylharpagide was significantly cytotoxic.