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Tissue Engineering of the Urethra: A Systematic Review and Meta-analysis of Preclinical and Clinical Studies.
TLDR
It is shown that improvements to (pre)clinical study design is required to improve clinical translation of tissue engineering technologies, and improved ( Preclinical study designs may enhance clinical translation. Expand
Ureteral tissue engineering: where are we and how to proceed?
TLDR
It is concluded that the available literature is inconclusive since the superiority of a specific scaffold has not been demonstrated and the latest developments of regenerative medicine have not been evaluated in ureteral tissue engineering yet. Expand
TIGIT blockade enhances functionality of peritoneal NK cells with altered expression of DNAM-1/TIGIT/CD96 checkpoint molecules in ovarian cancer
TLDR
Investigation of the role of the DNAM-1/TIGIT/CD96 axis in the anti-tumor response of NK cells toward OC shows for the first time that checkpoint molecules TigIT/DNAM- 1/ CD96 play an important role inNK cell responsiveness against OC, and provides rationale for incorporating TIGIT interference in NK cell-based immunotherapy in OC patients. Expand
The effect of a cyclic uniaxial strain on urinary bladder cells
TLDR
Mechanical stimuli did not enhance the proliferation and differentiation of urothelial cells and preconditioning may improve the functional in vivo outcome of smooth muscle cell seeded constructs for flexible organs such as the bladder. Expand
Visualisation of newly synthesised collagen in vitro and in vivo
TLDR
A universal strategy to detect and localize newly deposited collagen based on its inherent association with dermatan sulfate is developed, applicable irrespective of host species and collagen source. Expand
Recent Advances in Ureteral Tissue Engineering
TLDR
In this review, the most recent published data regarding ureteral tissue engineering are presented and evaluated, with a focus on cell sources, implantation strategies, and (bio)materials. Expand
Bladder Regeneration Using Multiple Acellular Scaffolds with Growth Factors in a Bladder.
TLDR
Implantation of multiple collagen-heparin scaffolds in one bladder is feasible in a porcine model, resulting in tissue almost indistinguishable from native tissue involving all cell layers of the bladder. Expand
Reconstruction Strategies of the Ureter and Urinary Diversion Using Tissue Engineering Approaches.
TLDR
It is indicated that regeneration of ureteral tissue and the formation of a urinary diversion using TE approaches are possible, although it is currently very time-consuming and complex to achieve well-developed neotissue. Expand
Ureteral Reconstruction in Goats Using Tissue-Engineered Templates and Subcutaneous Preimplantation.
TLDR
The use of preimplanted tissue templates showed favorable results compared with direct functional implantation of the templates, and partial remodeling toward autologous tissue and similar mechanical characteristics likely improved the integration in the ureteral tissue. Expand
The Impact of γ-Irradiation and EtO Degassing on Tissue Remodeling of Collagen-based Hybrid Tubular Templates
TLDR
The effect of sterilization on tissue remodeling cannot be predicted by in vitro analyses alone and validated sterilization methods should be incorporated early in the development of tissue engineered products, and this requires both in vitro and in vivo analyses. Expand
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