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Blebbistatin: use as inhibitor of muscle contraction
Blebbistatin (BLEB) is a recently discovered compound that inhibits myosin-II ATPase activity. In this study, we tested BLEB in intact and skinned isolated rat cardiac trabeculae, rat intactExpand
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Mechanisms of Ca2+ handling in zebrafish ventricular myocytes
The zebrafish serves as a promising transgenic animal model that can be used to study cardiac Ca2+ regulation. However, mechanisms of sarcoplasmic reticulum (SR) Ca2+ handling in the zebrafish heartExpand
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Cardiac thin filament regulation
Myocardial contraction is initiated upon the release of calcium into the cytosol from the sarcoplasmic reticulum following membrane depolarization. The fundamental physiological role of the heart isExpand
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Altered contractile function in heart failure
The syndrome of congestive heart failure (CHF) is an entity of ever increasing clinical significance. CHF is characterized by a steady decrease in cardiac pump function which is eventually lethal.Expand
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Interventricular differences in myofilament function in experimental congestive heart failure
This study was conducted to identify molecular mechanisms which explain interventricular differences in myofilament function in experimental congestive heart failure (CHF). CHF was induced in rats byExpand
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Differential contribution of cardiac sarcomeric proteins in the myofibrillar force response to stretch
The present study examined the contribution of myofilament contractile proteins to regional function in guinea pig myocardium. We investigated the effect of stretch on myofilament contractileExpand
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Cardiac myosin binding protein-C: redefining its structure and function
Mutations of cardiac myosin binding protein-C (cMyBP-C) are inherited by an estimated 60 million people worldwide, and the protein is the target of several kinases. Recent evidence further suggestsExpand
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Force and velocity of sarcomere shortening in trabeculae from rat heart. Effects of temperature.
The effect of temperature on the force-sarcomere velocity relation (20 degrees, 25 degrees, and 30 degrees C) and maximum velocity of sarcomere shortening (Vo; range 15 degrees-35 degrees C) wasExpand
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Lack of effect of isoproterenol on unloaded velocity of sarcomere shortening in rat cardiac trabeculae.
Several recent reports have indicated that catecholamines may act directly on the crossbridge cycle, independent of intracellular calcium concentration changes. The present study investigated theExpand
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Pathogenic properties of the N-terminal region of cardiac myosin binding protein-C in vitro
Cardiac myosin binding protein-C (cMyBP-C) plays a role in sarcomeric structure and stability, as well as modulating heart muscle contraction. The 150 kDa full-length (FL) cMyBP-C has been shown toExpand
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