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Hypoparathyroidism in the adult: Epidemiology, diagnosis, pathophysiology, target‐organ involvement, treatment, and challenges for future research
This review, which focuses primarily on hypoparathyroidism in the adult, provides a comprehensive summary of the latest information on this disease. Expand
Development of a Novel Immunoradiometric Assay Exclusively for Biologically Active Whole Parathyroid Hormone 1–84: Implications for Improvement of Accurate Assessment of Parathyroid Function
It is identified that the previously described non‐(1–84)PTH fragments are aminoterminally truncated with similar hydrophobicity as PTH(7–84), and these PTH fragments will be present not only in patients with secondary hyperparathyroidism (2°‐HPT) of uremia, but also in Patients with primary hyper parathyroidistan (1°‐hPT) and normal persons. Expand
Diagnosis of asymptomatic primary hyperparathyroidism: proceedings of the third international workshop.
OBJECTIVE Asymptomatic primary hyperparathyroidism (PHPT) is a common clinical problem. The purpose of this report is to guide the use of diagnostic tests for this condition in clinical practice. Expand
Accumulation of a non-(1-84) molecular form of parathyroid hormone (PTH) detected by intact PTH assay in renal failure: importance in the interpretation of PTH values.
A molecular form of PTH different from PTH-(1-84) and present in normal serum is recognized by two-site intact (I-) PTH assays and accumulates in renal failure and accounts for a larger proportion of I-PTH than that in normal subjects. Expand
Synthetic carboxyl-terminal fragments of parathyroid hormone (PTH) decrease ionized calcium concentration in rats by acting on a receptor different from the PTH/PTH-related peptide receptor.
It is suggested that C-PTH fragments, particularly hPTH-(7-84), can influence the Ca(2+) concentration negatively in vivo and limit in such a way the calcemic responses to hPth-(1-84) and hP THrP-1-34 by interacting with a receptor different from the PTH/PTHrP receptor. Expand
Diagnosis of asymptomatic primary hyperparathyroidism: proceedings of the Fourth International Workshop.
It is concluded that reference ranges should be established for serum PTH in vitamin D-replete healthy individuals and genetic testing has the potential to be useful in the differential diagnosis of familial hyperparathyroidism or hypercalcemia. Expand
A non-(1-84) circulating parathyroid hormone (PTH) fragment interferes significantly with intact PTH commercial assay measurements in uremic samples.
The results suggest that most of the two-site I-PTH assays would cross-react with non-(1-84)PTH material, thus explaining about one-half of the 2-2.5 x higher I-pTH concentrations reported in uremic patients without bone involvement than in subjects without uremia. Expand
Amino-terminal form of parathyroid hormone (PTH) with immunologic similarities to hPTH(1-84) is overproduced in primary and secondary hyperparathyroidism.
This new molecular form of PTH has structural integrity of the (1-4) region but presumably is modified in the region (15-20), which is usually recognized by the T-PTH assay, and its clinical implications remain to be defined. Expand
Structure of non-(1-84) PTH fragments secreted by parathyroid glands in primary and secondary hyperparathyroidism.
The results indicate that non-(1-84) PTH fragments are composed of a family of fragments which may be generated by specific or progressive cleavage at the N region. Expand
Influence of glomerular filtration rate on non-(1-84) parathyroid hormone (PTH) detected by intact PTH assays.
The importance of non-1-84 PTH in the composition of I-PTH increased with each GFR decrease, being 21% in healthy individuals, 32% in progressive renal failure patients with a GFR <30 mL, and 50% in hemodialyzed patients, with PTH(1- 84) making up the difference. Expand