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Drug Delivery Systems: Entering the Mainstream
Drug delivery systems (DDS) such as lipid- or polymer-based nanoparticles can be designed to improve the pharmacological and therapeutic properties of drugs administered parenterally. Many of theExpand
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Vesicles of variable sizes produced by a rapid extrusion procedure.
Previous studies from this laboratory have shown that large unilamellar vesicles can be efficiently produced by extrusion of multilamellar vesicles through polycarbonate filters with a pore size ofExpand
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Liposomal drug delivery systems: from concept to clinical applications.
The first closed bilayer phospholipid systems, called liposomes, were described in 1965 and soon were proposed as drug delivery systems. The pioneering work of countless liposome researchers overExpand
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Production of large unilamellar vesicles by a rapid extrusion procedure: characterization of size distribution, trapped volume and ability to maintain a membrane potential.
A technique for the rapid production of large unilamellar vesicles by repeated extrusion under moderate pressures (≤ 500 lb/in²) of multilamellar vesicles through polycarbonate filters (100 nm poreExpand
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Rational design of cationic lipids for siRNA delivery
We adopted a rational approach to design cationic lipids for use in formulations to deliver small interfering RNA (siRNA). Starting with the ionizable cationic lipidExpand
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Solute distributions and trapping efficiencies observed in freeze-thawed multilamellar vesicles.
It has recently been observed (Gruner, Lenk, Janoff and Ostro (1985) Biochemistry, in the press) that mechanical dispersion of dry lipid in an aqueous buffer to form multilamellar vesicle (MLV)Expand
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Association of blood proteins with large unilamellar liposomes in vivo. Relation to circulation lifetimes.
The proteins associated with liposomes in the circulation of mice were analyzed in order to determine whether bound proteins significantly influence the fate of liposomes in vivo. Liposomes wereExpand
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Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: formation of novel small multilamellar vesicle structures.
Typical methods used for encapsulating antisense oligodeoxynucleotides (ODN) and plasmid DNA in lipid vesicles result in very low encapsulation efficiencies or employ cationic lipids that exhibitExpand
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Developments in liposomal drug delivery systems
Liposomes are the leading drug delivery systems for the systemic (iv.) administration of drugs. There are now liposomal formulations of conventional drugs that have received clinical approval andExpand
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Chapter 1 Physical properties and functional roles of lipids in membranes
Publisher Summary Membrane lipids satisfy demands related to membrane structure, fluidity, and permeability as well as protein association and function. This chapter describes the physical propertiesExpand
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