Decreased basal fMRI functional connectivity in epileptogenic networks and contralateral compensatory mechanisms
A better understanding of interstructure relationship sustaining drug‐resistant epileptogenic networks is crucial for surgical perspective and to better understand the consequences of epileptic…
Magnetic resonance study of the influence of tissue damage and cortical reorganization on PASAT performance at the earliest stage of multiple sclerosis
- B. Audoin, My Van Au Duong, P. Cozzone
- Psychology, MedicineHuman Brain Mapping
- 1 March 2005
This study indicates that even at the earliest stage of MS, cortical reorganization is present inside the executive system of working memory and could tend to limit the determinant functional impact of NAWM injury on the execution of the PASAT.
Atrophy mainly affects the limbic system and the deep grey matter at the first stage of multiple sclerosis
- B. Audoin, W. Zaaraoui, J. Ranjeva
- Medicine, PsychologyJournal of Neurology Neurosurgery & Psychiatry
- 14 April 2010
It is demonstrated that regional GM atrophy is present right after the first clinical event of multiple sclerosis and mainly affects the deep GM and the limbic system.
Assessing brain connectivity at rest is clinically relevant in early multiple sclerosis
Findings suggest that resting state functional MRI may represent a promising surrogate marker of disease burden in patients with early relapsing–remitting multiple sclerosis.
Compensatory cortical activation observed by fMRI during a cognitive task at the earliest stage of multiple sclerosis
- B. Audoin, D. Ibarrola, P. Cozzone
- Psychology, BiologyHuman Brain Mapping
- 1 October 2003
The present study argues in favor of the existence of compensatory cortical activations at the earliest stage of multiple sclerosis mainly located in regions involved in executive processing in patients performing PASAT and suggests that fMRI can evidence the active processes of neuroplasticity contributing to mask the clinical cognitive expression of brain pathology at the early stage of MS.
Graph theoretical analysis of structural and functional connectivity MRI in normal and pathological brain networks
- M. Guye, G. Bettus, F. Bartolomei, P. Cozzone
- Psychology, BiologyMagnetic Resonance Materials in Physics, Biology…
- 27 March 2010
Graph theoretical analysis of connectivity MRI data provides an outstanding framework to merge anatomical and functional data in order to better understand brain pathologies and brings new insights into a better understanding of pathophysiology of many neurological or psychiatric diseases affecting specific local or global brain networks.
Citrulline/malate promotes aerobic energy production in human exercising muscle
- D. Bendahan, J. Mattei, B. Ghattas, S. Confort-Gouny, M. Le Guern, P. Cozzone
- MedicineBritish Journal of Sports Medicine
- 1 August 2002
The changes in muscle metabolism produced by CM treatment indicate that CM may promote aerobic energy production, which may be the result of an enhanced malate supply activating ATP production from the tricarboxylic acid cycle through anaplerotic reactions.
Imaging Experimental Cerebral Malaria In Vivo: Significant Role of Ischemic Brain Edema
- Marie-France Penet, A. Viola, P. Cozzone
- MedicineJournal of Neuroscience
- 10 August 2005
These findings demonstrate the coexistence of inflammatory and ischemic lesions and prove the preponderant role of edema in the fatal outcome of experimental cerebral malaria, and improve the understanding of the pathogenesis of cerebral malaria.
Role of resting state functional connectivity MRI in presurgical investigation of mesial temporal lobe epilepsy
- G. Bettus, F. Bartolomei, M. Guye
- Medicine, PsychologyJournal of Neurology Neurosurgery & Psychiatry
- 14 June 2010
This study demonstrates that the presence of BFC increases in the non-epileptic side was paradoxically the most specific marker of epileptogenic zone localisation, and suggests that a single resting-state fcMRI could be useful in the presurgical assessment of MTLE at an individual level.
Heterogeneity of muscle recruitment pattern during pedaling in professional road cyclists: a magnetic resonance imaging and electromyography study
- F. Hug, D. Bendahan, Y. le Fur, P. Cozzone, L. Grélot
- BiologyEuropean Journal of Applied Physiology
- 20 April 2004
This high level of variation in the recruitment of lower limb muscles in professional cyclists during both incremental and constant-load exercises is surprising given the homogeneity related to maximal oxygen consumption and training volume.
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