Nutritional status is a prognostic factor for survival in ALS patients
- J. Desport, P. Preux, T. Truong, J. Vallat, D. Sautereau, P. Couratier
- MedicineNeurology
- 1 September 1999
The degree of malnutrition is independent of neurologic scores and of forms of ALS onset, both in bulbar-onset and spinal-ONSet patients, and nutritional surveillance of ALS patients is very important.
TARDBP mutations in motoneuron disease with frontotemporal lobar degeneration
- L. Benajiba, I. Le Ber, A. Brice
- BiologyAnnals of Neurology
- 1 April 2009
TARDBP mutations are described in two patients with FTLD‐MND, presenting with a behavioral variant of FTLD and semantic dementia, suggesting that TDP‐43 may also have a direct pathogenic role in FTLD disorders.
Genome-wide Analyses Identify KIF5A as a Novel ALS Gene
- A. Nicolas, K. Kenna, N. Twine
- BiologyNeuron
- 21 March 2018
Descriptive epidemiology of amyotrophic lateral sclerosis: new evidence and unsolved issues
- G. Logroscino, B. Traynor, E. Beghi
- BiologyJournal of Neurology Neurosurgery & Psychiatry
- 13 December 2007
The contribution of the various population based registers is outlined, the limitations of the existing datasets are identified and a mechanism to improve the future design and output of descriptive epidemiological studies is proposed.
Hypermetabolism in ALS patients: an early and persistent phenomenon
- C. Bouteloup, J. Desport, P. Couratier
- Medicine, BiologyJournal of Neurology
- 22 March 2009
About 50% of ALS patients are hypermetabolic, and 80% show no change in metabolic status over time, confirming that metabolic status (a clinically useful indicator of the need for nutritional support) can be determined early in the evolution of the disease.
Factors correlated with hypermetabolism in patients with amyotrophic lateral sclerosis.
- J. Desport, P. Preux, P. Couratier
- Medicine, BiologyAmerican Journal of Clinical Nutrition
- 1 September 2001
This study corroborates the surprising finding that ALS patients are hypermetabolic and investigates the factors correlated with metabolic level.
SOD1, ANG, VAPB, TARDBP, and FUS mutations in familial amyotrophic lateral sclerosis: genotype–phenotype correlations
- S. Millecamps, F. Salachas, V. Meininger
- Biology, MedicineJournal of Medical Genetics
- 24 June 2010
Clinical comparison of SOD1, TARDBP, FUS and other familial ALS patients (with no mutation in the screened genes) revealed differences in site of onset, age of onset (younger with FUS mutations), and in lifespan (shorter for FUS carriers).
Alteration of nutritional status at diagnosis is a prognostic factor for survival of amyotrophic lateral sclerosis patients
- B. Marin, J. Desport, P. Couratier
- MedicineJournal of Neurology Neurosurgery & Psychiatry
- 19 November 2010
Nutritional parameters of ALS patients worsened during evolution of the disease, and worse nutritional status (at time of diagnosis or during the course) was associated with a higher mortality.
Variation in worldwide incidence of amyotrophic lateral sclerosis: a meta-analysis
- B. Marin, F. Boumédiène, E. Beghi
- MedicineInternational Journal of Epidemiology
- 13 May 2016
A systematic review and meta-analysis of population-based data published to date confirms a heterogeneous distribution worldwide of ALS, and sets the scene to sustain a collaborative study involving a wide international consortium to investigate the link between ancestry, environment and ALS incidence.
Nutritional assessment and survival in ALS patients.
- J. Desport, P. Preux, C. Truong, L. Courat, J. Vallat, P. Couratier
- MedicineAmyotrophic Lateral Sclerosis and other Motor…
- 2000
Enteral nutrition support can improve the respiratory status of ALS patients, and percutaneous endoscopic gastrostomy tube placement is well tolerated, and provides more efficient enteral nutrition than nasogastric tube feeding.
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