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Epidemiological data on Staphylococcus aureus strains producing synergohymenotropic toxins.
DNA hybridisation of 309 consecutive Staphylococcus aureus clinical isolates with oligonucleotide probes specific for genes encoding Panton-Valentine leucocidin (luk-PV) and gamma-haemolysin (hlg)Expand
Panton-Valentine leucocidin and gamma-hemolysin from Staphylococcus aureus ATCC 49775 are encoded by distinct genetic loci and have different biological activities
The cosecretion of these five proteins led to six possible synergistic combinations between F and S components, two of which had dermonecrotic activity on rabbit skin, and all six were leukocytolytic on glass-adsorbed leukocytes. Expand
Molecular epidemiology of human herpesvirus 8 in africa: both B and A5 K1 genotypes, as well as the M and P genotypes of K14.1/K15 loci, are frequent and widespread.
Analysis of 52 new HHV8 strains by sequencing the complete hypervariable K1 gene and genotyping the K14.1/K15 loci revealed an overall predominance of P subtype, except in the A5 and B K1 groups, in which the P and M alleles were equally represented. Expand
American histoplasmosis in developing countries with a special focus on patients with HIV: diagnosis, treatment, and prognosis
Direct examination of May–Grünwald–Giemsa-stained smears or tissues in suspected histoplasmosis is a simple means of confirming the diagnosis in resource-poor settings and further refine indication criteria to guide first-line treatment choice between amphotericin B and itraconazole. Expand
Monoclonality or oligoclonality of human herpesvirus 8 terminal repeat sequences in Kaposi's sarcoma and other diseases.
The finding that nodular KS lesions display all possible patterns of clonality supports the model according to which KS begins as a polyclonal disease with subsequent evolution to a monoclonal process, suggesting that HHV8 infection precedes tumor growth and thus supporting an etiologic role of latentHHV8 in these proliferations. Expand
Histoplasmosis and acquired immunodeficiency syndrome: a study of prognostic factors.
It is found that dyspnea, a platelet count of <100,000 platelets/mm3, and lactate dehydrogenase levels of >2 times the upper limit of the normal range were significantly independently associated with the death of the patient during the first 30 days of antifungal treatment. Expand
Histoplasmosis in HIV-Infected Patients: A Review of New Developments and Remaining Gaps
Progress has been made in DNA patterns of strains and understanding of pathogenesis, and hopefully these will help identify new therapeutic targets and new diagnostic tools and therapeutics developments have still not been made available in most endemic regions. Expand
Increased expression of telomere length regulating factors TRF1, TRF2 and TIN2 in patients with adult T‐cell leukemia
The results underscore the importance of telomerase and telomere length regulating factors as novel markers for ATL disease progression and as potential therapeutic targets for the treatment of HTLV‐I‐associated malignancies. Expand
Intralesional Regulatory T-Cell Suppressive Function during Human Acute and Chronic Cutaneous Leishmaniasis Due to Leishmania guyanensis
The role of intralesional Treg cells in the immunopathogenesis of human Leishmania infection, particularly in CCL patients is confirmed, since they preferentially accumulate in lesions from ACL patients during the early phase of infection. Expand
Serological and molecular evidence that human herpesvirus 8 is endemic among Amerindians in French Guiana.
Seroprevalence was higher in Amerindians living in remote localities than it was in those living in the coastal region, and analysis of a 725-base pair fragment of the K1 gene amplified from DNA from a Wayampi Amerindian showed that the virus belonged to molecular subtype E, which has hitherto been found in only a few Amerindia in Brazil and Ecuador. Expand