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Structure-activity relationship study of biflavonoids on the Dengue virus polymerase DENV-NS5 RdRp.
Over the four different biflavonoid skeletons tested, amentoflavone and robustaflavone are the most promising ones for antidengue drug development, and Sotetsuflavone is the most active compound of this series and is the strongest inhibitor of the Dengue virus NS5 RNA-dependent RNA polymerase described in the literature. Expand
Biflavonoids of Dacrydium balansae with potent inhibitory activity on dengue 2 NS5 polymerase.
P podocarpusflavone A is the strongest noncytotoxic non-nucleotide molecule exhibiting a specific inhibitory activity against the RNA polymerase domain of DV-NS5 and thus is promising for chemotherapy development against dengue fever. Expand
New Inhibitors of the DENV-NS 5 RdRp from Carpolepis laurifolia as Potential Antiviral Drugs for Dengue Treatment
Since a few decades the dengue virus became a major public health concern and no treatment is available yet. In order to propose potential antide ngue compounds for chemotherapy we focused on DENV R… Expand
Standardized LC×LC-ELSD Fractionation Procedure for the Identification of Minor Bioactives via the Enzymatic Screening of Natural Extracts.
- P. Coulerie, Y. Ratinaud, +9 authors D. Barron
- Biology, Medicine
- Journal of natural products
- 28 October 2016
The automated fractionation methodology presented demonstrated high efficiency for the detection of bioactive compounds at low abundance in plant extracts for high-throughput screening. Expand
Phytochemical Study of Myrtopsis corymbosa, Perspectives for Anti-dengue Natural Compound Research
In order to find new molecules for anti-viral drug design, we screened 102 ethyl acetate extracts obtained from 51 plants native from New-Caledonia f or an antiviral activity against the dengue 2… Expand
New Caledonia: A ‘Hot Spot’ for Valuable Chemodiversity. Part 1: Gymnosperms
The chemical information available on New Caledonian native flora from economical perspectives is reviewed to expect that a better knowledge of the economic potential will encourage the plantation of native plants for the development of a sustainable economy which will participate in the conservation of biodiversity. Expand
Chemical Originalities of New Caledonian Liverworts from Lejeuneaceae Family
- P. Coulerie, L. Thouvenot, M. Nour, Y. Asakawa
- Biology, Medicine
- Natural product communications
- 1 September 2015
The terpenoid content of twelve New Caledonian species, including two endemics, is described, for the first time, the presence of frullanolide in the Lejeuneaceae, occurring as a major compound in the extract from Colura leratii, and a rarely observed santalene derivative from Acrolejeunea securifolia subsp. Expand
New Caledonia: A ‘ Hot Spot’ for Valuable Chemodiversity
This review highlights several plants and groups, such as Amborella sp. Expand
Improving the detection of plant bioactive compounds by coupling a semi-preparative 2D-LCxLC system to an HTS platform.