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Unacylated Ghrelin Induces Oxidative Stress Resistance in a Glucose Intolerance and Peripheral Artery Disease Mouse Model by Restoring Endothelial Cell miR-126 Expression
It is demonstrated that UnAG is able to protect skeletal muscle and endothelial cells (ECs) from ROS imbalance in hind limb ischemia–subjected ob/ob mice by rescuing miR-126 expression, thus emphasizing its potential clinical impact in avoiding limb loss in PAD. Expand
Peripherally inserted central catheters in non-hospitalized cancer patients: 5-year results of a prospective study
The main findings of this study were that, if accurately managed, PICCs can be safely used in cancer patients receiving chemotherapy and/or HPN, recording a low incidence of CRBSI, thrombosis, and mechanical complications; a long catheter life span; and a low probability of catheter removal because of complications. Expand
Catheter-related complications in cancer patients on home parenteral nutrition: a prospective study of over 51,000 catheter days.
- P. Cotogni, M. Pittiruti, C. Barbero, T. Monge, A. Palmo, D. Boggio Bertinet
- JPEN. Journal of parenteral and enteral nutrition
- 1 May 2013
In cancer patients, HPN can be safely carried out with a low incidence of complications, and strict adherence to meticulous insertion policies may effectively reduce catheter-related complications. Expand
Arachidonic and docosahexaenoic acids reduce the growth of A549 human lung-tumor cells increasing lipid peroxidation and PPARs.
- A. Trombetta, M. Maggiora, G. Martinasso, P. Cotogni, R. Canuto, G. Muzio
- Biology, Medicine
- Chemico-biological interactions
- 20 February 2007
Results showed that both n-6PUFAs and n-3 PUFAs decrease human lung-tumor cell growth in a concentration-dependent manner, inducing cell death mainly evident at 100microM concentration. Expand
Focus on peripherally inserted central catheters in critically ill patients.
Evidence from the medical literature and from the clinical practice supports the belief that, compared to CICCs, the so-called power-injectable peripherally inserted central catheters are a good alternative choice in critical care. Expand
Unacylated Ghrelin Promotes Skeletal Muscle Regeneration Following Hindlimb Ischemia via SOD‐2–Mediated miR‐221/222 Expression
- G. Togliatto, A. Trombetta, +6 authors M. Brizzi
- Journal of the American Heart Association
- 1 December 2013
It is shown that UnAG but not acylated ghrelin (AG) induces skeletal muscle regeneration in response to ischemia via canonical p38/mitogen‐actived protein kinase signaling UnAG protected against reactive oxygen species–induced cell injuries by inducing the expression of superoxide dismutase‐2 (SOD‐2) in satellite cells. Expand
Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study
- A. Rautanen, Tara C. Mills, +35 authors C. Hinds
- The Lancet. Respiratory medicine
- 1 January 2015
Common variants in the FER gene and associated molecular pathways are potential novel targets for therapy or prevention and candidates for the development of biomarkers for risk stratification. Expand
Longitudinal study of quality of life in advanced cancer patients on home parenteral nutrition
Global QoL, physical, role, and emotional functioning improved during HPN even in advanced cancer patients on oncologic treatments, and physical functioning, Physical functioning, role functioning, emotional functioning, appetite loss, and fatigue scores had a statistically significant trend over time. Expand
Awareness and consideration of malnutrition among oncologists: Insights from an exploratory survey.
Although malnutrition and nutritional support seemed to be perceived by the responders as relevant factors for the efficacy of oncologic treatments, it seems that nutritional care practices may well be inappropriate. Expand
Deep sternal wound infection after cardiac surgery: Evidences and controversies.
The careful control of patient and surgical risk factors - when possible, the proper antimicrobial prophylaxis, and the choice of validated techniques of treatment could contribute to keep DSWIs at a minimal rate. Expand