P. Cossart

Publications541
h-index122
Citations50,540
Highly Influential Citations2,983
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Guidelines for the use and interpretation of assays for monitoring autophagy
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the… Expand
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Comparative Genomics of Listeria Species
Listeria monocytogenes is a food-borne pathogen with a high mortality rate that has also emerged as a paradigm for intracellular parasitism. We present and compare the genome sequences of L.… Expand
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The Listeria transcriptional landscape from saprophytism to virulence
The bacterium Listeria monocytogenes is ubiquitous in the environment and can lead to severe food-borne infections. It has recently emerged as a multifaceted model in pathogenesis. However, how this… Expand
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Bacterial Invasion: The Paradigms of Enteroinvasive Pathogens
Invasive bacteria actively induce their own uptake by phagocytosis in normally nonphagocytic cells and then either establish a protected niche within which they survive and replicate, or disseminate… Expand
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A single amino acid in E‐cadherin responsible for host specificity towards the human pathogen Listeria monocytogenes
Human E‐cadherin promotes entry of the bacterial pathogen Listeria monocytogenes into mammalian cells by interacting with internalin (InlA), a bacterial surface protein. Here we show that mouse… Expand
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Entry of L. monocytogenes into cells is mediated by internalin, a repeat protein reminiscent of surface antigens from gram-positive cocci
We report the identification of a previously unknown gene, inlA, which is necessary for the gram-positive intracellular pathogen Listeria monocytogenes to invade cultured epithelial cells. The inlA… Expand
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A Transgenic Model for Listeriosis: Role of Internalin in Crossing the Intestinal Barrier
Listeria monocytogenes is responsible for severe food-borne infections, but the mechanisms by which bacteria cross the intestinal barrier are unknown. Listeria monocytogenes expresses a surface… Expand
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Entry of Listeria monocytogenes into hepatocytes requires expression of InIB, a surface protein of the internalin multigene family
The intracellular bacterium Listeria monocytogenes can invade several types of normally non‐phagocytic cells. Entry into cultured epithelial cells requires the expression of inIA, the first gene of… Expand
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An RNA Thermosensor Controls Expression of Virulence Genes in Listeria monocytogenes
In Listeria monocytogenes, virulence genes are maximally expressed at 37 degrees C, almost silent at 30 degrees C and controlled by PrfA, a transcriptional activator whose expression is… Expand
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Transcriptome analysis of Listeria monocytogenes identifies three groups of genes differently regulated by PrfA
PrfA is the major regulator of Listeria virulence gene expression. This protein is a member of the Crp/Fnr family of transcription regulators. To gain a deeper understanding of the PrfA regulon, we… Expand
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