• Publications
  • Influence
Evaluation of transcutol as a clonazepam transdermal permeation enhancer from hydrophilic gel formulations.
The influence of diethyleneglycol monoethyl ether (transcutol), alone or in combination with propylene glycol, on clonazepam permeation through an artificial membrane and excised rabbit ear skin fromExpand
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In vitro study of clonazepam diffusion kinetics from solutions or hydrophilic gel.
Preliminary studies were conducted to evaluate the influence of temperature, pH and ionic strength of the donor and receptor medium on the solubility, partition coefficient and diffusion rate ofExpand
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Near infrared transmittance analysis for the assay of solid pharmaceutical dosage forms.
The recent commercial availability of near infrared spectrometric instruments for the transmittance analysis of solids makes it possible to analyse solid drugs in their finished form. Application ofExpand
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Application of near-infrared reflectance spectrometry in the study of atopy. Part 1. Investigation of skin spectra.
An investigation into the existence of spectral differences and differences in response in terms of water and lipid content between normal and atopic skin is described. Since NIR radiation penetratesExpand
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In vitro studies of simulated percutaneous absorption: influence of various enhancers in the release of clonazepam from 2-hydroxyethyl acetate patches.
A diffusion cell with an artificial membrane and the single-pass perfused rabbit ear were used to evaluate the percutaneous absorption of clonazepam from various 2-hydroxyethyl acetate (HEA) patches.Expand
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The single-pass perfused rabbit ear as a model for studying percutaneous absorption of clonazepam. II. Influence of hydrogel-borne propylene glycol and skin pretreatment with lauryl alcohol.
Enhancers of the percutaneous diffusion of clonazepam in the isolated single-pass perfused rabbit ear were evaluated and included propylene glycol (PG), polyethylene glycols (PEGs) of differentExpand
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The single-pass perfused rabbit ear as a model for studying percutaneous absorption of clonazepam. I. General characteristics.
A single-pass perfused rabbit ear was employed as the model for studying percutaneous absorption of clonazepam in an open perfusion system. Clonazepam at 1.5% concentration (w/w) was suspended in aExpand
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Effect of presence and type of lipophilic compound on the in vitro diffusion of clonazepam from hydrophilic ointment bases
The effect was investigated of adding to the vehicle three different kinds of lipid compounds (lauryl alcohol, isopropylmiristate or vaseline oil) on the release of clonazepam from hydrophilicExpand
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Formulation factors influencing the release of clonazepam from a carbopol hydrogel.
A study of formulation factors influencing the release of clonazepam from a Carbopol hydrogel through a cellulose nitrate membrane impregnated with lauryl alcohol was performed using two diffusionExpand
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