P. Connolly

Publications14
h-index10
Citations305
Highly Influential Citations9
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Predicting the human in vivo performance of different oral capsule shell types using a novel in vitro dynamic gastric model.
The disintegration of a capsule shell may determine the onset of drug dissolution from capsule formulations. In this study, the release of a rapidly dissolving model drug (paracetamol), from two… Expand
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MRI studies of the hydrodynamics in a USP 4 dissolution testing cell.
We present a detailed study of hydrodynamics inside the flow-through dissolution apparatus when operated according to USP recommendations. The pulsatile flow inside the flow-through cell was measured… Expand
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Ranitidine bismuth citrate: a novel anti‐ulcer agent with different physico‐chemical characteristics and improved biological activity to a bismuth citrate‐ranitidine admixture.
BACKGROUND: Ranitidine bismuth citrate (RBC) is a new chemical entity for the treatment of peptic ulcer disease. RESULTS: RBC is freely soluble in water (more than 600 mg/mL at pH 4.6), whereas an… Expand
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The pharmacokinetics and pharmacodynamics of danirixin (GSK1325756) − a selective CXCR2 antagonist − in healthy adult subjects
BackgroundExcessive neutrophil presence and activation is important in a number of acute and chronic inflammatory diseases. The CXCR2 chemokine receptor is important in controlling the extravasation… Expand
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Use of Surface Charges from DFT Calculations To Predict Intestinal Absorption
TLDR
A model for prediction of percent intestinal absorption (%Abs) of neutral molecules was developed based upon surface charges of the molecule calculated by density functional theory (DFT). Expand
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A critical evaluation of the defined daily dose (DDD) Methodology
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Use of a gastro-intestinal model and gastroplus[tm] for the prediction of in vivo performance
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Cyclin-dependent kinase 12, a novel drug target for visceral leishmaniasis
Visceral leishmaniasis causes considerable mortality and morbidity in many parts of the world. There is an urgent need for the development of new, effective treatments for this disease. Here we… Expand
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On-line solution stability determination of pharmaceuticals by capillary electrophoresis
SummaryGood agreement between the impurity levels in a batch of a related impurity of ranitidine were obtained by CE and HPLC. A solution of the impurity was positioned on the CE autosampler and… Expand
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Identification and characterisation of a salt form of Danirixin with reduced pharmacokinetic variability in patient populations
Graphical abstract Figure. No caption available. ABSTRACT The natural variability of gastric pH or gastric acid reducing medications can result in lower and more variable clinical pharmacokinetics… Expand
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