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A Mutation in the TRPC6 Cation Channel Causes Familial Focal Segmental Glomerulosclerosis
Focal and segmental glomerulosclerosis (FSGS) is a kidney disorder of unknown etiology, and up to 20% of patients on dialysis have been diagnosed with it. Here we show that a large family withExpand
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Acute renal failure following cardiac surgery.
BACKGROUND Acute renal failure requiring dialysis (ARF-D) occurs in 1.5% of patients following cardiac surgery, and remains a cause of major morbidity and mortality. While some preoperative riskExpand
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Catheter-Related Bacteremia and Outcome of Attempted Catheter Salvage in Patients Undergoing Hemodialysis
See related articles on pp 257-266 and 267-274. Single-lumen central venous catheters were introduced in the 1970s. In the 1980s, dual-lumen, tunneled, cuffed catheters were developed and became anExpand
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A population‐based study of skin cancer incidence and prevalence in renal transplant recipients
Background  Cancers occurring following solid organ transplantation are a rapidly growing public health concern. Defining the extent of the problem has been limited by surveillance systems withExpand
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C3 glomerulopathy: clinicopathologic features and predictors of outcome.
BACKGROUND AND OBJECTIVES The term C3 glomerulopathy describes renal disorders characterized by the presence of glomerular deposits composed of C3 in the absence of significant amounts of Ig. On theExpand
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Rare hereditary COL4A3/COL4A4 variants may be mistaken for familial focal segmental glomerulosclerosis
Focal segmental glomerulosclerosis (FSGS) is a histological lesion with many causes including inherited genetic defects with significant proteinuria being the predominant clinical finding atExpand
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The association of lowest hematocrit during cardiopulmonary bypass with acute renal injury after coronary artery bypass surgery.
BACKGROUND Acute renal injury is a common serious complication of cardiac surgery. Moderate hemodilution is thought to reduce the risk of kidney injury but the current practice of extremeExpand
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Progression of renal artery stenosis in patients undergoing cardiac catheterization.
BACKGROUND Renal artery stenosis is potentially correctable by either revascularization surgery or percutaneous methods. However, appropriate use of these techniques has been hampered by a lack ofExpand
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Severity of renal vascular disease predicts mortality in patients undergoing coronary angiography.
BACKGROUND Renal artery stenosis (RAS) is a relatively uncommon but potentially reversible cause of renal failure. In a previous report, we demonstrated that the presence of RAS is independentlyExpand
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Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS.
FSGS is characterized by segmental scarring of the glomerulus and is a leading cause of kidney failure. Identification of genes causing FSGS has improved our understanding of disease mechanisms andExpand
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