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Rap1 Regulates the Formation of E-Cadherin-Based Cell-Cell Contacts
- C. Hogan, N. Serpente, +6 authors Yasuyuki Fujita
- Medicine, Biology
- Molecular and Cellular Biology
- 1 August 2004
ABSTRACT In epithelial tissues, cells are linked to their neighbors through specialized cell-cell adhesion proteins. E-cadherin is one of the most important membrane proteins for the establishment of… Expand
Sonic hedgehog and the molecular regulation of mouse neural tube closure.
Neural tube closure is a fundamental embryonic event whose molecular regulation is poorly understood. As mouse neurulation progresses along the spinal axis, there is a shift from midline neural plate… Expand
Specific isoforms of protein kinase C are essential for prevention of folate-resistant neural tube defects by inositol.
- P. Cogram, A. Hynes, Louisa P E Dunlevy, N. Greene, A. Copp
- Biology, Medicine
- Human molecular genetics
- 28 October 2003
A proportion of neural tube defects (NTDs) can be prevented by maternal folic acid supplementation, although some cases are unresponsive. The curly tail mutant mouse provides a model of… Expand
Multiple Behavior Phenotypes of the Fragile-X Syndrome Mouse Model Respond to Chronic Inhibition of Phosphodiesterase-4D (PDE4D)
- M. Gurney, P. Cogram, R. Deacon, Christopher Rex, M. Tranfaglia
- Scientific Reports
- 7 November 2017
Fragile-X syndrome (FXS) patients display intellectual disability and autism spectrum disorder due to silencing of the X-linked, fragile-X mental retardation-1 (FMR1) gene. Dysregulation of cAMP… Expand
D-chiro-inositol is more effective than myo-inositol in preventing folate-resistant mouse neural tube defects.
BACKGROUND Among mouse genetic mutants that develop neural tube defects (NTDs), some respond to folic acid administration during early pregnancy, whereas NTDs in other mutants are not prevented. This… Expand
NNZ-2566, a Novel Analog of (1–3) IGF-1, as a Potential Therapeutic Agent for Fragile X Syndrome
AbstractFragile X syndrome (FXS) is the most common form of inherited intellectual disability. Previous studies have implicated mGlu5 in the pathogenesis of the disease, and many agents that target… Expand
Neurulation and neural tube closure defects.
CBP/p300-interacting transactivator, with Glu/Asp-rich C-terminal domain, 2, and pre-B-cell leukemia transcription factor 1 in human adrenal development and disease.
- B. Ferraz-de-Souza, Franziska Martin, +8 authors J. Achermann
- Biology, Medicine
- The Journal of clinical endocrinology and…
- 1 February 2009
CONTEXT Disorders of adrenal development result in significant morbidity and mortality. However, the molecular basis of human adrenal development, and many forms of disease, is still poorly… Expand
Dementia in Latin America
The demographic structure of Latin American countries (LAC) is fast approaching that of developing countries, and the predicted prevalence of dementia in the former already exceeds the latter.… Expand
Gaboxadol Normalizes Behavioral Abnormalities in a Mouse Model of Fragile X Syndrome
- P. Cogram, R. Deacon, J. Warner-Schmidt, Melanie von Schimmelmann, B. Abrahams, M. During
- Front. Behav. Neurosci.
- 10 April 2018
Fragile X syndrome (FXS) is the most common inherited form of intellectual disability and autism. FXS is also accompanied by attention problems, hyperactivity, anxiety, aggression, poor sleep,… Expand