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The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease
We demonstrate that this “Connectivity Map” resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. Expand
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Regulation of Ferroptotic Cancer Cell Death by GPX4
Ferroptosis is a form of nonapoptotic cell death for which key regulators remain unknown. We sought a common mediator for the lethality of 12 ferroptosis-inducing small molecules. We used targetedExpand
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Correlating chemical sensitivity and basal gene expression reveals mechanism of action
Changes in cellular gene expression in response to small-molecule or genetic perturbations have yielded signatures that can connect unknown mechanisms of action (MoA) to ones previously established.Expand
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Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset.
UNLABELLED Identifying genetic alterations that prime a cancer cell to respond to a particular therapeutic agent can facilitate the development of precision cancer medicines. Cancer cell-line (CCL)Expand
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Insulin antibodies in insulin-dependent diabetics before insulin treatment.
A sensitive assay was used to measure the binding of iodine-125-labeled insulin in serum obtained from 112 newly diagnosed insulin-dependent diabetics before insulin treatment was initiated. TwoExpand
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An Interactive Resource to Identify Cancer Genetic and Lineage Dependencies Targeted by Small Molecules
The high rate of clinical response to protein-kinase-targeting drugs matched to cancer patients with specific genomic alterations has prompted efforts to use cancer cell line (CCL) profiling toExpand
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Predicting Cancer-Specific Vulnerability via Data-Driven Detection of Synthetic Lethality
Synthetic lethality occurs when the inhibition of two genes is lethal while the inhibition of each single gene is not. It can be harnessed to selectively treat cancer by identifying inactive genes inExpand
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Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway
Plasticity of the cell state has been proposed to drive resistance to multiple classes of cancer therapies, thereby limiting their effectiveness. A high-mesenchymal cell state observed in humanExpand
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Target identification and mechanism of action in chemical biology and drug discovery.
Target-identification and mechanism-of-action studies have important roles in small-molecule probe and drug discovery. Biological and technological advances have resulted in the increasing use ofExpand
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ChemBank: a small-molecule screening and cheminformatics resource database
ChemBank (http://chembank.broad.harvard.edu/) is a public, web-based informatics environment developed through a collaboration between the Chemical Biology Program and Platform at the Broad Institute of Harvard and MIT. Expand
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