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Induction of angiogenic cytokine expression in cultured RPE by ingestion of oxidized photoreceptor outer segments.
- G. Higgins, J. Wang, P. Dockery, P. Cleary, H. Redmond
- Biology, Medicine
- Investigative ophthalmology & visual science
- 1 April 2003
PURPOSE Normal aging is associated with accumulation of lipofuscin pigment in the retinal pigment epithelium (RPE). This may occur as a result of phagocytosis and incomplete degradation of oxidized… Expand
Method of production and natural history of experimental posterior penetrating eye injury in the rhesus monkey.
We developed an experimental model for a posterior penetrating eye injury that resulted in traction retinal detachment in 21 rhesus monkey eyes. The standard injury was an incision through the pars… Expand
Elevated aqueous humour tissue inhibitor of matrix metalloproteinase-1 and connective tissue growth factor in pseudoexfoliation syndrome
Background/aims: Pseudoexfoliation syndrome (PXF) was recently found to be associated with increased expression of transforming growth factor β1 (TGFβ1) in the aqueous humour. As concern has been… Expand
Histology of wound, vitreous, and retina in experimental posterior penetrating eye injury in the rhesus monkey.
We performed a histologic study to support our clinical observations on the mechanisms responsible for traction retinal detachment after a penetrating injury in the rhesus monkey eye. The monkey eyes… Expand
Retinitis pigmentosa and retinal oedema.
Twenty-five patients with retinitis pigmentosa and retinal leakage were investigated. Oedema was present in dominant and X-linked inherited disease and is likely to be present in recessive disease as… Expand
Vitrectomy in penetrating eye injury. Results of a controlled trial of vitrectomy in an experimental posterior penetrating eye injury in the rhesus monkey.
A controlled trial of pars plana vitrectomy for posterior penetrating eye injury was done in rhesus monkeys. After standard injury, each eye was allocated randomly into a treatment or control group.… Expand
Ultrastructure of traction retinal detachment in rhesus monkey eyes after a posterior penetrating ocular injury.
We studied the ultrastructural characteristics of an experimental model of traction retinal detachment secondary to a penetrating eye injury in the rhesus monkey. Cells with the characteristics of… Expand
Macular abnormalities in the reattached retina.
Sixty-six patients in whom the macula was detached before surgery were observed for at least 1 year after retinal reattachment. Macular abnormalities were recognised clinically in most patients with… Expand
Experimental posterior penetrating eye injury in the rabbit. I. Method of production and natural history.
A technique has been developed which produces an experimental posterior penetrating eye injury that reproducibly results in traction retinal detachment in rabbit eyes. The standard injury is an… Expand
Optical coherence tomographic pattern may predict visual outcome after intravitreal triamcinolone for diabetic macular edema.
OBJECTIVE To identify an optical coherence tomography (OCT) pattern predictive of visual outcome in patients with diabetic macular edema (DME) who underwent a single dose of intravitreal… Expand