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The effects of nicotine on locomotor activity in non‐tolerant and tolerant rats
1 Rats were tested for locomotor activity in photocell cages, for 80 min starting immediately after subcutaneous injection of (−)‐nicotine bitartrate or 0.9%w/v NaCl solution (saline). InExpand
Characterization of the locomotor stimulant action of nicotine in tolerant rats
1 Tests of locomotor activity (photocell cages) were used to investigate the development of tolerance to nicotine in rats. Repeated exposure to the apparatus did not influence the rate at whichExpand
Release of [3H]‐noradrenaline from rat hippocampal synaptosomes by nicotine: mediation by different nicotinic receptor subtypes from striatal [3H]‐dopamine release
1 The aim of the present experiment was to characterize nicotine‐evoked [3H]‐noradrenaline ([3H]‐NA) release from rat superfused hippocampal synaptosomes, using striatal [3H]‐dopamine release forExpand
International Union of Pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits.
Nicotinic acetylcholine receptors (nACh receptors2) in jawed vertebrates are prototypical members of the multisubunit, neurotransmitter-gated superfamily of ion channels (ionotropic neurotransmitterExpand
Evidence that mesolimbic dopaminergic activation underlies the locomotor stimulant action of nicotine in rats.
L-Nicotine stimulates locomotor activity in rats which have had prior experience of the drug. The present study investigated whether this behavioral effect is related to activation of the mesolimbicExpand
Antihyperalgesic effects of delta opioid agonists in a rat model of chronic inflammation.
Opioid receptors in the brain activate descending pain pathways to inhibit the nociceptive response to acute noxious stimuli. The aim of the present study was to clarify the role of supraspinalExpand
Autoradiographic evidence for nicotine receptors on nigrostriatal and mesolimbic dopaminergic neurons
Rats received unilateral injections of 6-hydroxydopamine into the medial forebrain bundle, resulting in an ipsilateral loss of striatal dopamine and of dopaminergic perikarya. A concomitant reductionExpand
Antihyperalgesic effects of δ opioid agonists in a rat model of chronic inflammation
Opioid receptors in the brain activate descending pain pathways to inhibit the nociceptive response to acute noxious stimuli. The aim of the present study was to clarify the role of supraspinalExpand
Nicotinic binding in rat brain: autoradiographic comparison of (/sup 3/H)acetylcholine, (/sup 3/H)nicotine, and (/sup 125/I)-alpha-bungarotoxin
Three radioligands have been commonly used to label putative nicotinic cholinoceptors in the mammalian central nervous system: the agonists (/sup 3/H)nicotine and (/sup 3/H)acetylcholine ((/supExpand
Chronic central nicotinic blockade after a single administration of the bisquaternary ganglion‐blocking drug chlorisondamine
  • P. Clarke
  • Chemistry, Medicine
  • British journal of pharmacology
  • 1 October 1984
1 Drug‐naive rats were tested for horizontal and vertical activity in photocell cages, for up to 80 min starting immediately after a subcutaneous injection of (−)−nicotine bitartrate or 0.9% w/v NaClExpand
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