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The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus
Acquired immune deficiency syndrome (AIDS) is characterized by opportunistic infections and by ‘opportunistic neoplasms’ (for example, Kaposi's sarcoma)1. Persistent generalized lymphadenopathy (PGL)… Expand
The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain
The isolation of clones encoding the human surface protein T4, and the expression of the T4 gene in new cellular environments, have enabled us to examine the role of this protein in the pathogenesis… Expand
CD4-Independent Infection by HIV-2 Is Mediated by Fusin/CXCR4
Several members of the chemokine receptor family have been shown to function in association with CD4 to permit HIV-1 entry and infection. However, the mechanism by which these molecules serve as… Expand
Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist.
The chemokine receptors CXCR4 and CCR5 have recently been shown to act as coreceptors, in concert with CD4, for human immunodeficiency virus-type 1 (HIV-1) infection. RANTES and other chemokines that… Expand
The BBXB Motif of RANTES Is the Principal Site for Heparin Binding and Controls Receptor Selectivity*
- A. Proudfoot, S. Fritchley, +7 authors T. Wells
- Biology, Medicine
- The Journal of Biological Chemistry
- 6 April 2001
The chemokine RANTES (regulated on activation normal T cell expressed and secreted; CCL5) binds selectively to glycosaminoglycans (GAGs) such as heparin, chondroitin sulfate, and dermatan sulfate.… Expand
Cell surface receptors, virus entry and tropism of primate lentiviruses.
Human immunodeficiency virus (HIV) exploits cell surface receptors to attach to and gain entry into cells. The HIV envelope spike glycoprotein on the surface of virus particles binds both CD4 and a… Expand
Aminooxypentane-RANTES Induces CCR5 Internalization but Inhibits Recycling: A Novel Inhibitory Mechanism of HIV Infectivity
- M. Mack, B. Luckow, +10 authors A. Proudfoot
- Medicine, Biology
- The Journal of experimental medicine
- 20 April 1998
CCR5, a chemokine receptor expressed on T cells and macrophages, is the principal coreceptor for M-tropic HIV-1 strains. Recently, we described an NH2-terminal modification of the CCR5 ligand… Expand
Shared usage of the chemokine receptor CXCR4 by the feline and human immunodeficiency viruses.
- B. Willett, L. Picard, M. Hosie, J. D. Turner, K. Adema, P. Clapham
- Medicine, Biology
- Journal of virology
- 1 September 1997
Feline immunodeficiency virus (FIV) induces a disease state in the domestic cat that is similar to AIDS in human immunodeficiency virus (HIV)-infected individuals. As with HIV, FIV can be divided… Expand
Macrophages in Vaginal but Not Intestinal Mucosa Are Monocyte-Like and Permissive to Human Immunodeficiency Virus Type 1 Infection
ABSTRACT Mucosal surfaces play a major role in human immunodeficiency virus type 1 (HIV-1) transmission and pathogenesis, and yet the role of lamina propria macrophages in mucosal HIV-1 infection has… Expand
A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus.
Kaposi's sarcoma-associated herpesvirus encodes a chemokine called vMIP-II. This protein displayed a broader spectrum of receptor activities than any mammalian chemokine as it bound with high… Expand