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Recent progress in stereoselective synthesis with aldolases.
TLDR
Aldol reactions constitute a powerful methodology for carbon-carbon bond formation in synthetic organic chemistry and have been shown to be particularly valuable for obtaining new types of structures accessible for investigations in drug discovery. Expand
Asymmetric self- and cross-aldol reactions of glycolaldehyde catalyzed by D-fructose-6-phosphate aldolase.
TLDR
In the course of the investigations on the catalytic properties of FSA, a new and unexpected activity of paramount importance is discovered: its ability to catalyze the direct stereoselective cross-aldol addition of acetaldehyde to other aldehydes. Expand
“Green” amino acid-based surfactants
The value of amino acids and vegetable oil derivatives as raw materials for the preparation of surfactants was recognized as soon as they were discovered early in the last century. Amino acid-basedExpand
Amino acid-based surfactants
Abstract There is a pressing need for developing efficiently surfactants that are biodegradable and biocompatible. Surfactant molecules from renewable raw materials that mimic natural lipoamino acidsExpand
Enzymatic synthesis of a CCK‐8 tripeptide fragment in organic media
TLDR
The enzymatic synthesis of the tripeptide derivative Z‐Gly‐Trp‐Met‐OEt is reported, which is a fragment of the cholecystokinin C‐terminal octapeptide CCK‐8 and has an overall yield of 71%, including reaction and purification steps. Expand
Recombinant production of serine hydroxymethyl transferase from Streptococcus thermophilus and its preliminary evaluation as a biocatalyst
TLDR
The glyA gene encoding a serine hydroxymethyl transferase (SHMT) with threonine aldolase activity was isolated from Streptococcus thermophilus YKA-184 chromosomal DNA and showed potential as a biocatalyst for the stereoselective synthesis of β-hydroxy-α-amino acids. Expand
Structure-guided redesign of D-fructose-6-phosphate aldolase from E. coli: remarkable activity and selectivity towards acceptor substrates by two-point mutation.
Structure-guided re-design of the acceptor binding site of D-fructose-6-phosphate aldolase from E. coli leads to the construction of FSA A129S/A165G double mutant with an activity between 5- toExpand
Integrated Process for the Enzymatic Synthesis of the Octapeptide PhAcCCK‐8
TLDR
A process for the enzymatic synthesis of PhAcCCK‐8, the minimum sequence with biological activity of the cholecystokinin hormone, starting from amino acid derivatives as raw materials and employing proteases as biocatalysts for each peptide coupling. Expand
Reactivity of easily removable protecting groups for glycine in peptide synthesis using papain as catalyst
Abstract The reactivity of enzymatically removable protecting groups in peptide synthesis (phenyl acetyl and mandelyl) has been studied for the papain-catalyzed condensation between different n -αExpand
Interaction of antimicrobial arginine-based cationic surfactants with liposomes and lipid monolayers.
The present work examines the relationship between the antimicrobial activity of novel arginine-based cationic surfactants and the physicochemical process involved in the perturbation of the cellExpand
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