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Infection Process of the Hepatitis B Virus Depends on the Presence of a Defined Sequence in the Pre-S1 Domain
The results confirm the involvement of the L protein in the infection step and demonstrate that the sequence between amino acids 3 and 77 is involved in this process. Expand
Role of the Pre-S2 Domain of the Large Envelope Protein in Hepatitis B Virus Assembly and Infectivity
It is indicated that only 10% of the large-protein pre-S2 region at its N-terminal extremity is essential for virion export and that the remaining part, dispensable for viral secretion, is also dispensability for infectivity. Expand
Morphological changes in intracellular lipid droplets induced by different hepatitis C virus genotype core sequences and relationship with steatosis
It is shown that the core protein of both HCV genotypes 1b and 3a binds tightly to the surface of intracellular lipid droplets, which suggests that HCV core protein‐lipid droplet interaction could play a role in virus‐induced steatosis. Expand
The nonstructural 5A protein of hepatitis C virus genotype 1b does not contain an interferon sensitivity-determining region.
The findings show that there is no ISDR in the HCV genotype 1 NS5A protein and that theNS5A sequence does not influence the capacity of IFN- alpha to block viral replication, and does not rule out a role for NS5a in subsequent viral clearance. Expand
A Short N-Proximal Region in the Large Envelope Protein Harbors a Determinant That Contributes to the Species Specificity of Human Hepatitis B Virus
Infection by hepatitis B virus (HBV) is mainly restricted to humans, but this species specificity is likely determined at the early phase of the viral life cycle, and this short region of the L protein contributes to the host range of HBV. Expand
'Liver let die': oxidative DNA damage and hepatotropic viruses.
The evidence surrounding the mechanisms by which both viruses stimulate oxidative stress is reviewed, before focusing on how the viral proteins themselves may perturb the cellular response to oxidative DNA damage, impacting upon genome stability and thus hepatocarcinogenesis. Expand
Inhibition of hepatitis B virus production associated with high levels of intracellular viral DNA intermediates in iron-depleted HepG2.2.15 cells.
The results strongly suggest that iron depletion affects the HBV life cycle indirectly through the cell cycle arrest and directly through the inhibition of the viral DNA secretion and the need to re-evaluate with caution the iron depletion protocols on HBV infected patients. Expand
Habitat selection and density of couas in Madagascar: implication for their conservation.
By measuring vegetation characteristics and bird densities, it was possible to indicate which characteristics were important for these birds and which conservation measures would be necessary to apply for this forest. Expand
The impact of burning on the microhabitat used by two species of couas in the western dry forest of Madagascar
Habitat structure — an important consideration in all ecological studies of relationships between animals and their environment — can be studied at different scales. This topic was studied at theExpand
Hepatitis C Virus-Induced Hepatocellular Steatosis
Current knowledge of HCV-induced steatosis and its relation to chronic hepatitis C virus-associated liver disease is discussed. Expand