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Investigation of nonalcoholic fatty liver disease‐induced drug metabolism by comparative global toxicoproteomics
TLDR
NAFLD‐induced drug metabolism was investigated by comparative toxicoproteomics and significantly altered levels of CYPs and their activities induced by the MCD diet were identified and confirmed by pharmacokinetic analysis. Expand
Exploring the Metabolism of Loxoprofen in Liver Microsomes: The Role of Cytochrome P450 and UDP-Glucuronosyltransferase in Its Biotransformation
TLDR
CYP3A4 and CYP3A5 are identified as the major CYP isoforms involved in the hydroxylation of loxoprofen and its alcoholic metabolites, and it is identified that UGT2B7 is the major UGT isoform catalyzing the glucuronidation of l oxoproen and its alcohol metabolites. Expand
Characterization of CYPs and UGTs Involved in Human Liver Microsomal Metabolism of Osthenol
TLDR
This study elucidated the structure of generated metabolites using a high-resolution quadrupole-orbitrap mass spectrometer and characterized the major human cytochrome P450 and uridine 5′-diphospho-glucuronosyltransferase (UGT) isozymes involved in osthenol metabolism in human liver microsomes (HLMs). Expand
Identification of specific UGT1A9‐mediated glucuronidation of licoricidin in human liver microsomes
TLDR
Investigation of the metabolism of licoricidin in pooled human liver microsomes found it showed a higher metabolic ratio and rapid metabolism with the recombinant human UGT1A9 than mycophenolic acid, a well-known UGT2A9 substrate, which could serve as a new selective substrate to determine the activity of UGT 1A9 in vitro. Expand
Characterization of osthenol metabolism in vivo and its pharmacokinetics
TLDR
The quantitative method was validated in terms of linearity, accuracy, and precision and the BA of osthenol is low after oral administration, which was determined by LC-HR/MS analysis of the blood sample. Expand
Characterization of red ginseng-drug interaction by CYP3A activity increased in high dose administration in mice.
TLDR
The possibility of herb-drug interaction between the Korean red ginseng extract and cytochrome P450 (CYP) substrates in higher administration in mice is observed and interactions between KRG extract and CyP2D and CYP3A substrates at subchronic-high doses KRG administration in rats are observed. Expand
Identification of sulfonyl‐loxoprofen as novel phase 2 conjugate in rat
TLDR
This work characterized the metabolomic profile of loxoprofen in rat plasma, urine, and feces using high‐resolution mass spectrometry and identified 17 metabolites, two novel taurine conjugates and two novel acyl glucuronides were identified for the first time in rats. Expand
Characterization of hyperglycemia due to sub-chronic administration of red ginseng extract via comparative global proteomic analysis
TLDR
Novel evidence is provided that sub-chronic administration of KRG can elevate H2S production by increasing protein expression of CBS and CSE in the liver by promoting greater hydrogen sulfide (H2S) synthesis in the Liver. Expand
Assessing Drug Interaction and Pharmacokinetics of Loxoprofen in Mice Treated with CYP3A Modulators
TLDR
Concomitant use of LOX with CYP3A modulators may lead to drug–drug interactions and result in minor to severe toxicity even though there is no direct change in the metabolic pathway that forms the LOX active metabolite. Expand
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