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Structural Variations and Formation Constants of First-Row Transition Metal Complexes of Biologically Active Aroylhydrazones
Iron chelators of the 2-pyridinecarbaldehyde isonicotinoylhydrazone (HPCIH) class show high potential for the treatment of iron overload diseases. In the present study, selected first-row transitionExpand
Hydrazone chelators for the treatment of iron overload disorders: iron coordination chemistry and biological activity.
An extensive study of the Fe coordination chemistry of the HPCIH analogues including the first crystallographically characterised Fe(II) complex of these chelators, which indicates that their Fe chelation efficacy is due, at least in part, to the fact that these ligands and their Fe( II) complexes are neutral at physiological pH (7.4) and sufficiently lipophilic to permeate cell membranes. Expand
Novel diaroylhydrazine ligands as iron chelators: coordination chemistry and biological activity
Five new members of a series of N-aroyl-N′-picolinoyl hydrazine chelators showed high efficacy at mobilizing 59Fe from cells and inhibiting 59Fe uptake from the serum Fe transport protein, transferrin (Tf). Expand
Cytotoxic iron chelators: characterization of the structure, solution chemistry and redox activity of ligands and iron complexes of the di-2-pyridyl ketone isonicotinoyl hydrazone (HPKIH) analogues
Collectively, studies on the solution chemistry and structure of these HPKIH analogues indicate that they can bind cellular Fe and enhance its redox activity, resulting in oxidative damage to vital biomolecules. Expand
Unprecedented oxidation of a biologically active aroylhydrazone chelator catalysed by iron(III): serendipitous identification of diacylhydrazine ligands with high iron chelation efficacy
These data allow a model of Fe chelation for this compound to be proposed: the parent aroylhydrazone diffuses through cell membranes to bind Fe and is subsequently oxidized to the diacylhydrazine complex which then diffuses from the cell. Expand
Iron catalysed assembly of an asymmetric mixed-ligand triple helicate.
The 2-pyridinecarbaldehyde isonicotinoyl hydrazone (HPCIH) family of ligands are typically tridentate N,N,O chelators that exhibit very high in vitro activity in mobilizing intracellular Fe and areExpand