Author pages are created from data sourced from our academic publisher partnerships and public sources.
Regulation of Cytokine Receptors by Golgi N-Glycan Processing and Endocytosis
The Golgi enzyme β1,6 N-acetylglucosaminyltransferase V (Mgat5) is up-regulated in carcinomas and promotes the substitution of N-glycan with poly N-acetyllactosamine, the preferred ligand for… Expand
Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation.
- Yan Leng, J. Zhang, +5 authors K. Siminovitch
- Medicine, Biology
- Proceedings of the National Academy of Sciences…
- 25 January 2005
WAVE2 is a member of the Wiskott-Aldrich syndrome protein family of cytoskeletal regulatory proteins shown to link Rac activation to actin remodeling via induction of Arp 2/3 activity. WAVE2 is… Expand
Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3.
During the immediate-early response of mammalian cells to mitogens, histone H3 is rapidly and transiently phosphorylated by one or more unidentified kinases. Rsk-2, a member of the pp90rsk family of… Expand
Galectin Binding to Mgat5-Modified N-Glycans Regulates Fibronectin Matrix Remodeling in Tumor Cells
- A. Lagana, J. Goetz, P. Cheung, A. Raz, J. Dennis, I. Nabi
- Medicine, Biology
- Molecular and Cellular Biology
- 15 April 2006
ABSTRACT Oncogenic signaling stimulates the dynamic remodeling of actin microfilaments and substrate adhesions, essential for cell spreading and motility. Transformation is associated with increased… Expand
Inhibition of the sodium/potassium ATPase impairs N-glycan expression and function.
Aberrant N-linked glycans promote the malignant potential of cells by enhancing the epithelial-to-mesenchymal transition and the invasive phenotype. To identify small molecule inhibitors of N-glycan… Expand
Mgat5 and Pten interact to regulate cell growth and polarity.
Phosphatase and tensin homolog (Pten) phosphatase opposes intracellular phosphoinositide 3-kinase (PI3K)/Akt signaling and is a potent tumor suppressor, while Golgi beta1,6… Expand
UDP-N-acetylglucosamine:alpha-6-D-mannoside beta1,6 N-acetylglucosaminyltransferase V (Mgat5) deficient mice.
- J. Dennis, J. Pawling, P. Cheung, E. Partridge, M. Demetriou
- Biochimica et biophysica acta
Targeted gene mutations in mice that cause deficiencies in protein glycosylation have revealed functions for specific glycans structures in embryogenesis, immune cell regulation, fertility and cancer… Expand
Metabolic homeostasis and tissue renewal are dependent on beta1,6GlcNAc-branched N-glycans.
- P. Cheung, J. Pawling, E. Partridge, B. Sukhu, M. Grynpas, J. Dennis
- Biology, Medicine
- 1 August 2007
Golgi beta1,6-N-acetylglucosaminyltransferase V (Mgat5) produces beta1,6GlcNAc-branched N-glycans on glycoproteins, which increases their affinity for galectins and opposes loss from the cell surface… Expand
UDP-N-acetylglucosamine:α-6-d-mannoside β1,6 N-acetylglucosaminyltransferase V (Mgat5) deficient mice
Abstract Targeted gene mutations in mice that cause deficiencies in protein glycosylation have revealed functions for specific glycans structures in embryogenesis, immune cell regulation, fertility… Expand
Complex N-glycan and metabolic control in tumor cells.
Golgi beta1,6N-acetylglucosaminyltransferase V (Mgat5) produces beta1,6GlcNAc-branched complex N-glycans on cell surface glycoproteins that bind to galectins and promote surface residency of… Expand