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PLGA microspheres for the ocular delivery of a peptide drug, vancomycin using emulsification/spray-drying as the preparation method: in vitro/in vivo studies.
The aim of this study was an in vitro/in vivo investigation on poly(lactide-co-glycolide) (PLGA) microspheres as carriers for the topical ocular delivery of a peptide drug vancomycin (VA). TheExpand
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Solid lipid nanoparticles (SLN) as ocular delivery system for tobramycin.
Aim of this study was to evaluate solid lipid nanoparticles (SLN) as carriers for topical ocular delivery of tobramycin (TOB). The SLN were in the colloidal size range (average diameter below 100 nm;Expand
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Evaluation of ocular permeation enhancers: In vitro effects on corneal transport of four β-blockers, and in vitro/in vivo toxic activity
Abstract The efficacy and toxicity of a series of prospective ocular penetration enhancers (benzalkonium chloride, EDTA, non-ionic surfactants, surface-active heteroglycosides and bile salts) wasExpand
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Solid lipid nanoparticles as promising tool for intraocular tobramycin delivery: Pharmacokinetic studies on rabbits.
Eye drops are widely accepted as formulations for targeting the anterior segment notwithstanding their limitations in terms of bioavailability. The unique structure of the eye requiresExpand
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Pharmacokinetics and anti-inflammatory activity in rabbits of a novel indomethacin ophthalmic solution.
The formulation of aqueous ophthalmic solutions containing indomethacin (IND) presents serious problems due to poor solubility and stability of the drug. The purpose of this study was to evaluate aExpand
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Effect of different terpene-containing essential oils on permeation of estradiol through hairless mouse skin.
Purpose of the present investigation was to evaluate six terpene-containing essential oils for their capacity to promote permeation of estradiol (ES) through hairless mouse skin in vitro. Tests onExpand
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In Vitro Transungual Permeation of Ciclopirox from a Hydroxypropyl Chitosan-Based, Water-Soluble Nail Lacquer
Commercial antimycotic nail lacquers are commonly based on water-insoluble resins. The present study was aimed at evaluating a novel, experimental nail lacquer (P-3051, Polichem SA, Lugano,Expand
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Mucoadhesive ophthalmic vehicles: evaluation of polymeric low-viscosity formulations.
A series of polyanionic natural or semi-synthetic polymers (polygalacturonic acid, hyaluronic acid, carboxymethylamylose, carboxymethylchitin, chondroitin sulfate, heparan sulfate and mesoglycan)Expand
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Larch arabinogalactan for dry eye protection and treatment of corneal lesions: investigations in rabbits.
PURPOSE The aim of the present study was to investigate the corneal protective and healing properties of arabinogalactan (AG), a natural polysaccharide present in conifers of the genus Larix (Larch).Expand
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Cytotoxicity of potential ocular permeation enhancers evaluated on rabbit and human corneal epithelial cell lines.
A series of prospective ocular permeation enhancers, benzalkonium chloride (BAC), cetylpyridinium chloride (CPC), ethylenediaminetetraacetic acid (EDTA), polyoxyethylene (20) stearyl ether (PSE) andExpand
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