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MicroRNA-133a, downregulated in osteosarcoma, suppresses proliferation and promotes apoptosis by targeting Bcl-xL and Mcl-1.
It is found that miR-133a was downregulated in osteosarcoma cell lines and primary human osteosARcoma tissues, and its decrease was significantly correlated with tumor progression and prognosis of the patients. Expand
Salinomycin Inhibits Proliferation and Induces Apoptosis of Human Hepatocellular Carcinoma Cells In Vitro and In Vivo
It is demonstrated that Sal inhibits proliferation and induces apoptosis of HCC cells in vitro and in vivo and one potential mechanism is inhibition of Wnt/β-catenin signaling via increased intracellular Ca2+ levels. Expand
Tumour-activated neutrophils in gastric cancer foster immune suppression and disease progression through GM-CSF-PD-L1 pathway
The results illuminate a novel mechanism of PD-L1 expression on tumour-activated neutrophils in GC, and provide functional evidence for these novel GM-CSF-PD-L 1 pathways to prevent, and to treat this immune tolerance feature of GC. Expand
Protective Effect of Astaxanthin on Liver Fibrosis through Modulation of TGF-β1 Expression and Autophagy
It was shown that 80 mg/kg astaxanthin had a significant protective effect on liver fibrosis by suppressing multiple profibrogenic factors. Expand
A pro-inflammatory role for Th22 cells in Helicobacter pylori-associated gastritis
This study identifies a novel regulatory network involving H. pylori, DCs, Th22 cells, gastric epithelial cells and MDSCs, which collectively exert a pro-inflammatory effect within the gastric microenvironment and efforts to inhibit this Th22-dependent pathway may prove a valuable strategy in the therapy of H.pylori-associated gastritis. Expand
Anti-miR-197 inhibits migration in HCC cells by targeting KAI 1/CD82.
The data suggest that anti-miR-197 suppresses HCC migration and invasion by targeting CD82, and the regulation of the miR- 197/CD82 axis could be a novel therapeutic target in future HCC effective therapy. Expand
Ethyl Pyruvate Ameliorates Hepatic Ischemia-Reperfusion Injury by Inhibiting Intrinsic Pathway of Apoptosis and Autophagy
The results showed that ethyl pyruvate might attenuate to hepatic I/R injury by inhibiting intrinsic pathway of apoptosis and autophagy, mediated partly through downregulation of HMGB1/TLR4/ NF-κb axis and the competitive interaction with Beclin-1 ofHMGB1. Expand
Role of gamma-delta T cells in host response against Staphylococcus aureus-induced pneumonia
Accumulation of γδ T cells in the lungs to S. aureus infection is beneficial for bacteria clearance and also contributes to the tissue damage. Expand
Ethyl pyruvate inhibits proliferation and induces apoptosis of hepatocellular carcinoma via regulation of the HMGB1-RAGE and AKT pathways.
  • P. Cheng, W. Dai, +12 authors L. Xu
  • Biology, Medicine
  • Biochemical and biophysical research…
  • 24 January 2014
It is demonstrated that ethyl pyruvate induces apoptosis and cell-cycle arrest in G phase in hepatocellular carcinoma cells, plays a critical role in the treatment of cancer. Expand
Ethyl Pyruvate Pretreatment Attenuates Concanavalin A-Induced Autoimmune Hepatitis in Mice
Results indicated that ethyl pyruvate protected against Con A-induced autoimmune hepatitis by decreasing both early (TNF-α,IL-2, IL-1β and IL-6) and late (HMGB1) cytokine expression in mice. Expand