• Publications
  • Influence
Analysis of LOXL1 polymorphisms in a United States population with pseudoexfoliation glaucoma
TLDR
An analysis of LOXL1 and XFG in a United States patient population and has confirmed the strong association previously reported for Icelandic and Swedish samples, however, due to the high frequency of risk alleles in non-XFG individuals, this association should not form the basis of a diagnostic test for XFG.
High failure rate associated with 180 degrees selective laser trabeculoplasty.
TLDR
Selective laser trabeculoplasty had an overall low success rate in the tertiary clinic population, with overall failure rates of 68% to 74% in those who underwent 180 degrees selective lasertrabecULoplasty.
Lack of association between LOXL1 variants and primary open-angle glaucoma in three different populations.
TLDR
LOXL1 gene variants do not appear to play a significant role in the pathogenesis of POAG in populations of either Caucasian or West-African ancestry.
Genetics of pseudoexfoliation syndrome
  • P. Challa
  • Medicine
    Current opinion in ophthalmology
  • 1 March 2009
TLDR
XFS is an important risk factor for glaucoma and lysyl oxidase-like 1 polymorphisms are strongly associated with XFS and the value of genetic testing for this disorder has not been validated.
Genome-wide expression profile of human trabecular meshwork cultured cells, nonglaucomatous and primary open angle glaucoma tissue.
TLDR
Comparative analysis between control and POAG tissues suggests that the upregulation of inflammation-associated genes might be involved in the progression of glaucoma.
Health literacy and adherence to glaucoma therapy.
TLDR
The subjects in this study with low literacy were less adherent with their glaucoma medications than those with a higher level of literacy and interventions specifically targeting patients with low Literacy may improve medication adherence.
A modeled economic analysis of a digital tele-ophthalmology system as used by three federal health care agencies for detecting proliferative diabetic retinopathy.
TLDR
Based on the economic model, the Joslin Vision Network has the potential to be more effective than clinic-based ophthalmoscopy for detecting proliferative diabetic retinopathy and averting cases of severe vision loss, and may do so at lower cost.
Induction of TGF‐β1 in the trabecular meshwork under cyclic mechanical stress
TLDR
Its induction after cyclic mechanical stress in the TM supports the hypothesis that this cytokine might play a significant role in the physiology of the TM, and contribute to the pathological changes of this tissue in certain forms of glaucoma.
Low prevalence of myocilin mutations in an African American population with primary open-angle glaucoma
TLDR
It is indicated that, despite the high prevalence of POAG, MYOC mutations are rare in the African American population.
A common variant near TGFBR3 is associated with primary open angle glaucoma
TLDR
Exome Array analysis on POAG cases and controls confirmed strong evidence of association at CDKN2B-AS1 and observed one SNP showing significant association to POAG, which has previously been shown to be strongly associated with optic disc area and vertical cup-to-disc ratio.
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