Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis.
- F. Giardiello, S. Hamilton, G. Offerhaus
- MedicineNew England Journal of Medicine
- 6 May 1993
Sulindac reduces the number and size of colorectal adenomas in patients with familial adenomatous polyposis, but its effect is incomplete, and it is unlikely to replace colectomy as primary therapy.
Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon
- J. Issa, Y. Ottaviano, P. Celano, S. Hamilton, N. Davidson, S. Baylin
- Biology, MedicineNature Genetics
- 1994
CpG island methylation appears in the oestrogen receptor (ER) gene in a subpopulation of cells which increases as a direct function of age in human colonic mucosa, and this same methylation change characterizes virtually all cells in all 45 colorectal tumours examined, including the earliest stages of tumour formation.
Isolation and characterization of the cDNA encoding human DNA methyltransferase.
- R. Yen, P. Vertino, S. Baylin
- BiologyNucleic Acids Research
- 11 May 1992
The arrangement of multiple motifs conserved in the prokaryotic genes is preserved in the human DNA MTase, including the relative position of a proline-cysteine dipeptide thought to be an essential catalytic site in all (cytosine-5)-methyltransferases.
Colorectal neoplasia in juvenile polyposis or juvenile polyps.
- F. Giardiello, S. Hamilton, S. Booker
- MedicineArchives of Disease in Childhood
- 1 August 1991
It is suggested that patients with juvenile polyps who have three or more juvenilePolyps or a family history of juvenile Polyps should undergo surveillance for colorectal neoplasia.
Separation of pluripotent haematopoietic stem cells from spleen colony-forming cells
- Richard J. Jones, J. Wagner, P. Celano, M. S. Zicha, S. Sharkis
- MedicineNature
- 13 September 1990
There are two vital classes of engrafting cells: committed progenitors, which provide initial, unsustained engraftment, and PHSC, which produce delayed, but durable, engraft-ment, which allows the lethally irradiated host to survive initial aplasia.
Randomized Phase II Trial of Carboplatin-Paclitaxel Versus Carboplatin-Paclitaxel-Trastuzumab in Uterine Serous Carcinomas That Overexpress Human Epidermal Growth Factor Receptor 2/neu.
Addition of trastuzumab to carboplatin-paclitaxel was well tolerated and increased progression-free survival, and no unexpected safety signals emerged.
Bias in treatment assignment in controlled clinical trials.
- T. Chalmers, P. Celano, H. Sacks, H. Smith
- Medicine, PsychologyNew England Journal of Medicine
- 1 December 1983
Differences in case-fatality rates between treatment and control groups were found, and the importance of keeping those who recruit patients for clinical trials from suspecting which treatment will be assigned to the patient under consideration is emphasized.
Increased cytosine DNA-methyltransferase activity during colon cancer progression.
- J. Issa, P. Vertino, S. Baylin
- Biology, MedicineJournal of the National Cancer Institute
- 4 August 1993
It is demonstrated that an increased DNA methylation capacity accompanies the increase in DNA-MTase transcripts observed during progressive stages of colon cancer, which is a risk factor for colon cancer.
High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer.
- W. El-Deiry, B. Nelkin, S. Baylin
- Biology, MedicineProceedings of the National Academy of Sciences…
- 15 April 1991
Increases in DNA methyltransferase gene expression precede development of colonic neoplasia and continue during progression of colonIC neoplasms, which may play a role in the genetic instability of cancer and mark early events in cell transformation.
Differential induction of spermidine/spermine N1-acetyltransferase in human lung cancer cells by the bis(ethyl)polyamine analogues.
- R. Casero, P. Celano, S. J. Ervin, C. Porter, R. Bergeron, P. Libby
- Biology, ChemistryCancer Research
- 15 July 1989
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