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A new steroidal alkylating agent with improved activity in advanced murine leukemias
SummaryThe homo-aza-steroidal ester of [p-[bis(2-chloroethyl)amino]phenoxy] acetic acid, 3β-hydroxy 13α-amino-13,17-seco-5α-androstan-17-oic-13,17-lactam-p-bis(2-chloroethyl)aminophenoxyacetate, gave… Expand
Antileukemic effect of homo-aza-steroidal ester of [p-[bis(2-chloroethyl)amino]phenyl]acetic acid.
The homo-aza-steroidal ester of [p-[bis(2-chloroethyl)amino]phenyl]acetic acid, 3beta-hydroxy-13alpha-amino-13,17-seco-5alpha-androstan-17-oic-13,17,-lactam p-bis(2-chloroethyl)aminophenylacetate… Expand
Mutagenic activity of the antitumour agent homo-aza-steroidal ester of p-N,N-bis(2-chloroethyl)aminophenoxyacetic acid (NSC 294859) in the Salmonella/microsome assay.
The mutagenic activity of the new antitumour agent 3 beta-hydroxy-13 alpha-amino-13,17-seco-5 alpha-androstan-17-oic-13,17-lactam- p-N,N-bis(2-chloroethyl)aminophenoxyacetate (NSC 294859) was studied… Expand
Activity of 3β-Hydroxy-13α-Amino-13,17-Seco-5α-Androstane-17-oic-13,17-Lactam(p-(bis(2-Chloroethyl)amino)-Phenyl)acetate (NSC 290205) in Murine Solid Tumors
The modified steroidal alkylating agent, 3 β -hydroxy-13α-amino-13,17-seco-5α-androstane-17-oic-13,17-lactam[p-[bis(2-chloroethyl)amino]-phenyl]acetate showed excellent activity in tr
Induction of cytogenetic damage by modified steroidal derivatives of p-bis(2-chloroethyl)aminophenylacetic acid in human lymphocytes.
- D. Mourelatos, C. Petrou, L. Boutis, A. Papageorgiou, P. Catsoulacos, J. Dozi-Vassiliades
- Biology, Medicine
- Mutation research
- 1 March 1987
The effect of modified steroids, containing alkylating agents, on SCE rates and on cell kinetics in cultured human lymphocytes was studied. The homo-aza-steroidal ester of… Expand
Steroidal 21-diazo ketones: photogenerated corticosteroid receptor labels.
The 21-diazo derivatives of 9 alpha-fluoro- and 9 alpha-bromo-21 deoxycorticosterone, 21-deoxycorticosterone, and progesterone were synthesized for use as photoaffinity labels for corticosteroid… Expand
Activity of 13β–Hydroxy–13α–amino–13,17-seco– 5α–androstan–17–oic–13,17–lactam–p–bis(2–chloro–ethyl)aminophenoxyacetate (NSC 294859) on Experimental Animal Tumor and Leukemia Systems
- P. Catsoulacos
- 1 July 1983
3 β -hydroxy-13α-amino-13,17-seco-5α-androstan-17-oic-13,17-lactam- p -bis(2-chloroethyl)amino-phenoxyacetate, a modified steroidal alkylating agent, is active in the
Chromosome damage and SCE induced by the cytostatic factor homo-aza-steroidal ester of P-bis (2-chloro-ethyl) amino phenyl acetic acid in CHO cells in culture.
The cytogenetic effects of homo-aza-steroidal ester (ASE) on Chinese hamster ovary (CHO) cells in vitro are reported. It was found that treatment of cells with a dose as low as 0.025 micrograms/ml of… Expand
Effect of a ▵5-Homo-Aza-Steroidal Ester in P388 and L1210 Murine Leukemias
3β-Hydroxy-13α-amino-13,17-seco-5-androsten-17-oic-13,17-lactam p-N, N-bis-(2-chloroethyl)-amino phenylacetate gives results in P388 and L1210 leukemias in mice, by the intraperitoneal route of… Expand
Induction of sister chromatid exchanges and cell division delays in human lymphocytes by the anti-tumour agent homo-aza-steroidal ester of p-bis(2-chloroethyl)aminophenoxy acetic acid.
3 beta-Hydroxy-13 alpha-amino-13,17-seco-5 alpha-androstan-17-oic-13,17-lactam-p-bis(2-chloroethyl) aminophenoxyacetate (NSC 294859) is a new modified steroidal alkylating agent. This compound was… Expand