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Endocannabinoid-mediated synaptic plasticity in the CNS.
- V. Chevaleyre, Kanji A. Takahashi, P. Castillo
- Biology, ChemistryAnnual Review of Neuroscience
- 15 June 2006
The eCB system is emerging as a major player in synaptic plasticity because it encompasses many forms of transient and long-lasting synaptic depression and is found at both excitatory and inhibitory synapses.
Endocannabinoid Signaling and Synaptic Function
Heterosynaptic LTD of Hippocampal GABAergic Synapses A Novel Role of Endocannabinoids in Regulating Excitability
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system.
The hypothesis that alpha-Syn is an essential presynaptic, activity-dependent negative regulator of DA neurotransmission is supported.
Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons
It is reported that repetitive activation of the hippocampal mossy fibre pathway, which is associated with high-affinity kainate binding and many of the kainATE receptor subtypes, generates a slow excitatory synaptic current with all of the properties expected of a kainates receptor.
RIM1α forms a protein scaffold for regulating neurotransmitter release at the active zone
It is shown that RIM1α, an active zone protein that was identified as a putative effector for the synaptic vesicle protein Rab3A, interacts with several active zone molecules, including Munc13-1 and α-liprins, to form a protein scaffold in the presynaptic nerve terminal that controls neurotransmitter release.
Mediation of hippocampal mossy fiber long-term potentiation by cyclic AMP.
It is proposed that calcium entry into the presynaptic terminal may activate Ca(2+)-calmodulin-sensitive adenylyl cyclase I which, through protein kinase A, causes a persistent enhancement of evoked glutamate release.
Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System
Rab3A is essential for mossy fibre long-term potentiation in the hippocampus
- P. Castillo, R. Janz, Thomas C. Sdhof, T. Tzounopoulos, R. Malenka, R. Nicoll
- 7 August 1997
It is shown that, although a variety of short-term plasticities are normal, LTP at mossy fibre synapses is abolished in mice lacking the synaptic vesicle protein Rab3A.
Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice
It is found that GluR6-deficient mice are less susceptible to systemic administration of kainate, as judged by onset of seizures and by the activation of immediate early genes in the hippocampus.