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Endocannabinoid-mediated synaptic plasticity in the CNS.
The eCB system is emerging as a major player in synaptic plasticity because it encompasses many forms of transient and long-lasting synaptic depression and is found at both excitatory and inhibitory synapses. Expand
Heterosynaptic LTD of Hippocampal GABAergic Synapses A Novel Role of Endocannabinoids in Regulating Excitability
A form of activity-dependent long-term depression at hippocampal inhibitory synapses that is triggered postsynaptically via glutamate receptor activation but is expressed presynaptically is described, which could account for the effects of cannabinoids on learning and memory. Expand
Endocannabinoid Signaling and Synaptic Function
New advances in synaptic endocannabinoid signaling in the mammalian brain are focused on and the emerging picture not only reinforcesendocannabinoids as potent regulators of synaptic function but also reveals that endoc cannabinoidoid signaling is mechanistically more complex and diverse than originally thought. Expand
RIM1α forms a protein scaffold for regulating neurotransmitter release at the active zone
It is shown that RIM1α, an active zone protein that was identified as a putative effector for the synaptic vesicle protein Rab3A, interacts with several active zone molecules, including Munc13-1 and α-liprins, to form a protein scaffold in the presynaptic nerve terminal that controls neurotransmitter release. Expand
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system.
The hypothesis that alpha-Syn is an essential presynaptic, activity-dependent negative regulator of DA neurotransmission is supported. Expand
Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons
It is reported that repetitive activation of the hippocampal mossy fibre pathway, which is associated with high-affinity kainate binding and many of the kainATE receptor subtypes, generates a slow excitatory synaptic current with all of the properties expected of a kainates receptor. Expand
Mediation of hippocampal mossy fiber long-term potentiation by cyclic AMP.
It is proposed that calcium entry into the presynaptic terminal may activate Ca(2+)-calmodulin-sensitive adenylyl cyclase I which, through protein kinase A, causes a persistent enhancement of evoked glutamate release. Expand
Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System
alpha-Synuclein (alpha-Syn) is a 14 kDa protein of unknown function that has been implicated in the pathophysiology of Parkinson's disease (PD). Here, we show that alpha-Syn-/- mice are viable andExpand
Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice
It is found that GluR6-deficient mice are less susceptible to systemic administration of kainate, as judged by onset of seizures and by the activation of immediate early genes in the hippocampus. Expand
RIM1alpha is required for presynaptic long-term potentiation.
The results indicate that the long-term increase in neurotransmitter release during mossy fibre LTP may be mediated by a unitary mechanism that involves the GTP-dependent interaction of Rab3A with RIM1alpha at the interface of synaptic vesicles and the active zone. Expand