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Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
TLDR
The presence of H3F3A/ATRX-DAXX/TP53 mutations was strongly associated with alternative lengthening of telomeres and specific gene expression profiles, suggesting that defects of the chromatin architecture underlie paediatric and young adult GBM pathogenesis. Expand
Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations
TLDR
This work integrated whole-genome sequencing with methylation, expression and copy number profiling, discovering that DIPGs comprise three molecularly distinct subgroups (H3-K27M, silent and MYCN) and uncovering a new recurrent activating mutation affecting the activin receptor gene ACVR1 in 20% of DIPG. Expand
Epigenomic alterations define lethal CIMP-positive ependymomas of infancy
TLDR
It is concluded that epigenetic modifiers are the first rational therapeutic candidates for this deadly malignancy, which is epigenetically deregulated but genetically bland. Expand
Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma.
TLDR
Subgroup-specific analysis reconciles prior conflicting publications and confirms that TP53 mutations are enriched among SHH medulloblastomas, in which they portend poor outcome and account for a large proportion of treatment failures in these patients. Expand
BRAF mutation and CDKN2A deletion define a clinically distinct subgroup of childhood secondary high-grade glioma.
TLDR
The prolonged course to transformation for BRAF V600E PLGGs provides an opportunity for surgical interventions, surveillance, and targeted therapies to mitigate the outcome of sHGG. Expand
Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study.
TLDR
Hypermethylation of the UTSS region in the TERT promoter is associated with TERT expression in cancers and is a potentially accessible biomarker for various cancers in paediatric brain tumours. Expand
Polypyrimidine Tract Binding Protein Modulates Efficiency of Polyadenylation
TLDR
It is shown that a fourfold overexpression of PTB results in a 75% reduction of mRNA levels produced from transfected gene constructs with different polyadenylation signals (pA signals). Expand
Alternative lengthening of telomeres is enriched in, and impacts survival of TP53 mutant pediatric malignant brain tumors
TLDR
The presence of ALT is limited to a specific group of childhood brain cancers which harbor somatic TP53 mutations and may influence the outcome of these patients, which may contribute to risk stratification and targeted therapies to improve outcome for these children. Expand
Cancer Stem Cells in Prostate Cancer: Implications for Targeted Therapy
TLDR
Therapies targeting CSCs might lead to more effective cancer treatments, divergent from a traditional anti-proliferative approach, based on tumor bulk reduction accompanied by CSC-specific inhibition. Expand
Trichostatin A and oncolytic HSV combination therapy shows enhanced antitumoral and antiangiogenic effects.
TLDR
Conurrent systemic TSA and intratumoral G47Delta administration resulted in enhanced antiangiogenesis and enhanced antitumoral efficacy in animal models, and combination treatment with oncolytic HSV provides a novel approach to cancer therapy. Expand
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