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Selective vulnerability and pruning of phasic motoneuron axons in motoneuron disease alleviated by CNTF
It is shown that in two mouse models of motoneuron disease, axons of fast-fatiguable motoneurons are affected synchronously, long before symptoms appear, and that mot oneuron disease involves predictable, selective vulnerability patterns by physiological subtypes of axons, episodes of abrupt pruning in the target region and compensation by resistant axons.
Early and Selective Loss of Neuromuscular Synapse Subtypes with Low Sprouting Competence in Motoneuron Diseases
The results reveal pronounced subtype specificity in the anatomical plasticity and susceptibility to loss of neuromuscular synapses and suggest that degenerative motoneuron diseases involve a common early pathway of selective and progressive synaptic weakening also associated with aging.
Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase
A mechanism for the regulation of cofilin and hence of actin dynamics in vivo is defined and should play a central role in regulating cell motility and morphogenesis by modulating the stability of act in cytoskeletal structures.
Perineuronal Nets Protect Fear Memories from Erasure
It is shown that intact PNNs mediate the formation of erasure-resistant fear memories and identifies a molecular mechanism closing a postnatal critical period during which traumatic memories can be erased by extinction.
A role for motoneuron subtype–selective ER stress in disease manifestations of FALS mice
The mechanisms underlying disease manifestations in neurodegeneration remain unclear, but their understanding is critical to devising effective therapies. We carry out a longitudinal analysis in vivo
Parvalbumin-expressing basket-cell network plasticity induced by experience regulates adult learning
A network plasticity mechanism induced after learning through VIP–PV microcircuit modulation, and involving large, sustained and reversible shifts in the configuration of PV basket-cell networks in the adult is uncovered and might be harnessed for therapeutic strategies to promote cognitive enhancement and neuroprotection.
Two membrane protein fractions from rat central myelin with inhibitory properties for neurite growth and fibroblast spreading
The data presented demonstrate the existence of membrane proteins with potent nonpermissive substrate properties and suggest that these proteins might play a crucial inhibitory role during development and regeneration in CNS white matter.
Gap43, Marcks, and Cap23 Modulate Pi(4,5p)2 at Plasmalemmal Rafts, and Regulate Cell Cortex Actin Dynamics through a Common Mechanism
It is suggested that GAP43, myristoylated alanine-rich C kinase substrate, and CAP23 are functionally and mechanistically related PI(4,5)P2 modulating proteins, upstream of actin and cell cortex dynamics regulation.