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Selective vulnerability and pruning of phasic motoneuron axons in motoneuron disease alleviated by CNTF
Neurodegenerative diseases can have long preclinical phases and insidious progression patterns, but the mechanisms of disease progression are poorly understood. Because quantitative accounts ofExpand
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Early and Selective Loss of Neuromuscular Synapse Subtypes with Low Sprouting Competence in Motoneuron Diseases
The addition or loss of synapses in response to changes in activity, disease, or aging is a major aspect of nervous system plasticity in the adult. The mechanisms that affect the turnover andExpand
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Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase
Cell division, cell motility and the formation and maintenance of specialized structures in differentiated cells depend directly on the regulated dynamics of the actin cytoskeleton,. To understandExpand
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Perineuronal Nets Protect Fear Memories from Erasure
Adult Fears Why are fear memories almost impossible to get rid of—even with extensive extinction training? Animal studies have shown that the efficacy of extinction learning depends on age. FearExpand
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A role for motoneuron subtype–selective ER stress in disease manifestations of FALS mice
The mechanisms underlying disease manifestations in neurodegeneration remain unclear, but their understanding is critical to devising effective therapies. We carry out a longitudinal analysis in vivoExpand
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MLP-Deficient Mice Exhibit a Disruption of Cardiac Cytoarchitectural Organization, Dilated Cardiomyopathy, and Heart Failure
MLP is a LIM-only protein of terminally differentiated striated muscle cells, where it accumulates at actin-based structures involved in cytoarchitecture organization. To assess its role in muscleExpand
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Parvalbumin-expressing basket-cell network plasticity induced by experience regulates adult learning
Learning and memory processes can be influenced by recent experience, but the mechanisms involved are poorly understood. Enhanced plasticity during critical periods of early life is linked toExpand
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Overexpression of growth-associated proteins in the neurons of adult transgenic mice
  • P. Caroni
  • Biology, Medicine
  • Journal of Neuroscience Methods
  • 31 January 1997
The Thy-1.2 expression cassette described in this report drives strong constitutive expression of transgenes specifically in the neurons of adult transgenic mice. Transgene expression begins atExpand
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Muscle LIM protein, a novel essential regulator of myogenesis, promotes myogenic differentiation
Muscle LIM protein (MLP) is a novel positive regulator of myogenesis. Its expression and that of its Drosophila homolog DMLP1 are enriched in striated muscle and coincide with myogenicExpand
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Gap43, Marcks, and Cap23 Modulate Pi(4,5p)2 at Plasmalemmal Rafts, and Regulate Cell Cortex Actin Dynamics through a Common Mechanism
The dynamic properties of the cell cortex and its actin cytoskeleton determine important aspects of cell behavior and are a major target of cell regulation. GAP43, myristoylated alanine-rich C kinaseExpand
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