• Publications
  • Influence
Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons
TLDR
It is found that when neurons were lethally challenged with excitatory amino acids or high K+, they experienced a biphasic increase characterized by a primary [Ca2+]i transient that decayed within minutes, followed by a secondary, sustained, and irreversible [ Ca2-i rise that indicated imminent cell death. Expand
Whole-cell recording of the Ca2+-dependent slow afterhyperpolarization in hippocampal neurones: effects of internally applied anions
TLDR
It is suggested that among anions commonly used in electrode filling solutions for whole-cell recordings, methylsulfate is the least disruptive to intracellular structures or Ca2+ homeostasis and permits stable whole- cell recording of the IAHP and Ca2-activated currents in mammalian CNS neurones. Expand
Oxidative stress is involved in seizure-induced neurodegeneration in the kindling model of epilepsy
TLDR
Antioxidants prevented the rise in lipid peroxides and hippocampal neuronal death during kindling, but did not arrest the development of seizures, suggesting epileptiform activity can result in free radical production which may be one of the factors leading to cell death. Expand
Patch-clamp study of postnatal development of CA1 neurons in rat hippocampal slices: membrane excitability and K+ currents.
TLDR
The postnatal development of membrane properties and outward K+ currents in CA1 neurons in rat hippocampal slices was studied with the use of whole-cell patch-clamp techniques, indicating a weak spike repolarizing mechanism at depolarized potentials. Expand
Development of GABA‐mediated, chloride‐dependent inhibition in CA1 pyramidal neurones of immature rat hippocampal slices.
TLDR
The present data indicate the existence of GABAA‐mediated inhibitory synaptic connections in CA1 neurones at the earliest stages of postnatal life. Expand
In vitro recordings of human neocortical oscillations.
TLDR
It is shown here that human cortical slices maintained in vitro can generate oscillations similar to those observed in vivo, and two types of activity, theta oscillations and high gamma activity, uniquely characterized this model-activity not typically observed in animal cortical slices. Expand
Model of frequent, recurrent, and spontaneous seizures in the intact mouse hippocampus
TLDR
The whole hippocampus with intact local circuitry, treated with low Mg2+, provides a realistic model of recurrent spontaneous seizures, which may be used to study the dynamics of seizures and seizure evolution, as well as the mechanisms of action of anti‐epileptic drugs and other therapeutic modalities. Expand
Potentiation of GABAA-mediated synaptic current by ethanol in hippocampal CA1 neurons: possible role of protein kinase C.
TLDR
It is demonstrated that ethanol potentiation of pharmacologically isolated GABAA IPSCs can be modulated by protein kinase C, and the active phorbol ester 4-beta-PDBu but not its inactive analog also interferes with ethanol enhancement of GAB AA IPSCs. Expand
Potentiation of a slow Ca(2+)-dependent K+ current by intracellular Ca2+ chelators in hippocampal CA1 neurons of rat brain slices.
TLDR
The hypothesis that when exogenous Ca2+ chelators become the predominant mobile Ca 2+ buffer in the neuron, they alter the shape of intracellular Ca2+, which provides insight into the mechanism of IsAHP generation is tested. Expand
N-type Ca2+ channels are located on somata, dendrites, and a subpopulation of dendritic spines on live hippocampal pyramidal neurons
TLDR
The distribution of N-type VDCCs on dendritic spines argues that these channels may participate in the generation of active Ca2+ conductances in distal dendrites, and is consistent with a role for spines as specialized compartments for concentrating Ca2+. Expand
...
1
2
3
4
...