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Reactive Oxygen Species Mediate Caspase Activation and Apoptosis Induced by Lipoic Acid in Human Lung Epithelial Cancer Cells through Bcl-2 Down-Regulation
TLDR
A novel pro-oxidant role of LA is indicated in apoptosis induction and its regulation by Bcl-2, which may be exploited for the treatment of cancer and related apoptosis disorders. Expand
Diabetic cardiomyopathy-associated dysfunction in spatially distinct mitochondrial subpopulations.
TLDR
It is indicated that diabetes mellitus imposes a greater stress on the IFM subpopulation, which is associated, in part, with increased superoxide generation and oxidative damage, resulting in morphological and functional abnormalities that may contribute to the pathogenesis of diabetic cardiomyopathy. Expand
Metabolism of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) by murine and human hepatic preparations.
TLDR
In vitro metabolism of 17 AAG by mouse and human hepatic preparations was studied to characterize the enzymes responsible for 17AAG metabolism and the structures of the metabolites produced, implying that metabolite 2 is a diol and metabolite 6 is an epoxide. Expand
Thermal Degradation Analysis of Amino Acids in Fingerprint Residue by Pyrolysis GC–MS to Develop New Latent Fingerprint Developing Reagents *
TLDR
To mimic scenarios where fingerprints may be exposed to high heat conditions, standards of the five most abundant amino acids in fingerprint residue as well as extracted fingerprint residue were pyrolized under controlled conditions and show products to hold promise as indicators of decomposed fingerprint residues. Expand
Reversible and irreversible protein glutathionylation: biological and clinical aspects
TLDR
Reversible protein glutathionylation is important in protecting proteins against oxidative stress, guiding correct protein folding, regulating protein activity and modulating proteins critical to redox signaling, and this has implications in disease and aging. Expand
CYP2C-catalyzed delta9-tetrahydrocannabinol metabolism: kinetics, pharmacogenetics and interaction with phenytoin.
TLDR
Surprisingly, delta9-THC increased the rate of phenytoin hydroxylation in human liver microsomes and expressed CYP2C9 enzyme, suggesting the potential for an interaction from the concomitant administration of delta9 -THC and pheny toin that could result in decreased phenyToin concentrations in vivo. Expand
Cysteine S-conjugate β-lyases: important roles in the metabolism of naturally occurring sulfur and selenium-containing compounds, xenobiotics and anticancer agents
TLDR
The cysteine S-conjugate β-lyases are biologically more important than hitherto appreciated in the metabolism/bioactivation of drugs and natural products. Expand
Esterase Inhibition by Grapefruit Juice Flavonoids Leading to a New Drug Interaction
TLDR
Overall, a series of flavonoids present in GFJ are identified as esterase inhibitors, of which kaempferol and naringenin are shown to mediate pharmacokinetic drug interaction with the prodrugs lovastatin and enalapril due to their capability of Esterase inhibition. Expand
Regulation of apoptosis by Bcl-2 cysteine oxidation in human lung epithelial cells
TLDR
These findings provide a novel redox regulatory mechanism that controls apoptosis via Bcl-2 cysteine oxidation, which could aid in the understanding of pathogenesis under oxidative stress conditions. Expand
Conversion of methamphetamine to N-methyl-methamphetamine in formalin solutions.
TLDR
Results from methamphetamine are reported, which is converted into its N-methyl derivative in the presence of formalin, with the greatest conversion occurring under basic conditions and the highest formalin concentration. Expand
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