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Sclareol inhibits cell proliferation and sensitizes cells to the antiproliferative effect of bortezomib via upregulating the tumor suppressor caveolin-1 in cervical cancer cells
It is demonstrated that sclareol inhibited tumor cell growth through the upregulation of Cav1, and provides a potential therapeutic target for human cancer.
In Silico Screening Identifies a Novel Potential PARP1 Inhibitor Targeting Synthetic Lethality in Cancer Treatment
- Jian Li, N. Zhou, P. Cai, J. Bao
- Biology, ChemistryInternational journal of molecular sciences
- 1 February 2016
Results indicated ZINC67913374 bound to PARP1 with a higher affinity, which suggest ZINC67813374 has promising potential for cancer drug development.
The diagnostic accuracy of digital PCR, ARMS and NGS for detecting KRAS mutation in cell-free DNA of patients with colorectal cancer: A systematic review and meta-analysis
Digital polymerase chain reaction, amplification refractory mutation system, and next-generation sequencing had overall high accuracy in detecting KRAS mutation in cell-free DNA sample.
Association between the PON1 Q192R polymorphism and coronary heart disease in Chinese
The present meta-analysis suggests that the PON1 Q192R polymorphism has a weak association with CHD risk in Chinese.
Dihydroartemisinin inhibits the viability of cervical cancer cells by upregulating caveolin 1 and mitochondrial carrier homolog 2: Involvement of p53 activation and NAD(P)H:quinone oxidoreductase 1…
- Ting Zhang, Yuan Hu, Ting Wang, P. Cai
- Biology, ChemistryInternational journal of molecular medicine
- 9 May 2017
This study identified Cav1 and MTCH2 as the molecular targets of DHA and revealed a new link between the upstream Cav1/MTCH2 upregulation and the downstream activation of the cell death pathway involved in the DHA-mediated inhibition of cell viability.
Osteoinduction of Calcium Phosphate Ceramics in Four Kinds of Animals for 1 Year: Dog, Rabbit, Rat, and Mouse.
Exercise enhance the ectopic bone formation of calcium phosphate biomaterials in muscles of mice.
PNAS4 knockout does not induce obviously neurocytes apoptosis and abnormal development in mice brain
- P. Cai, Xiaoqiang Xia, Fang-Hua Li, Yiyuan Cui, Qiaona Yang, Mina Chen
- BiologyMolecular Biology Reports
The data suggested that PNAS4 was not involved in mice brain development and apoptosis, and it was observed neither neural structural abnormality nor apoptosis signal in P NAS4 CKO mice brain.
Reliability of BRAF mutation detection using plasma sample
B-Raf mutation testing using plasma sample showed an overall high accuracy compared to paired tumor tissue sample, which could be used for cancer genotyping when tissue sample is not available.
Increased Sparsity of Hippocampal CA1 Neuronal Ensembles in a Mouse Model of Down Syndrome Assayed by Arc Expression
- C. Smith-Hicks, P. Cai, A. Savonenko, R. Reeves, P. Worley
- BiologyFront. Neural Circuits
- 3 February 2017
Reduction in the size of the behaviorally induced network that expresses Arc in Ts65Dn mice and disruption of the long-term stability of the ensemble are demonstrated and it is proposed that deficits in network formation and stability contribute to cognitive symptoms in DS.