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Efficient Generation of Myostatin Knock-Out Sheep Using CRISPR/Cas9 Technology and Microinjection into Zygotes
While CRISPR/Cas9 technology has proven to be a valuable system to generate gene-targeted modified animals in several species, this tool has been scarcely reported in farm animals. Myostatin isExpand
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Oocyte developmental competence is improved by relatively greater circulating progesterone concentrations during preovulatory follicular growth.
This study evaluated the effect of progesterone priming during follicular growth on oocyte competence to undergo oocyte cleavage and embryo development in sheep. Two experiments were performed on aExpand
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Serum progesterone concentrations during FSH superstimulation of the first follicular wave affect embryo production in sheep.
The aim of the present study was to evaluate the effect of serum progesterone concentrations during the superstimulatory treatment of the first follicular wave on fertilization rate and embryoExpand
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Embryo survival and birth rate after minimum volume vitrification or slow freezing of in vivo and in vitro produced ovine embryos.
The objective was to evaluate pregnancy outcomes and birth rate of in vivo derived vs. in vitro produced ovine embryos submitted to different cryopreservation methods. A total of 197 in vivo and 240Expand
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Time of ovulation and pregnancy outcomes obtained with the prostaglandin-based protocol Synchrovine for FTAI in sheep.
The objective of the present study was to determine the ovarian response induced with the prostaglandin-based protocol Synchrovine (two doses of PGF2α given 7 d apart), as well as the fertility afterExpand
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RAPID COMMUNICATION: Nerve growth factor influences cleavage rate and embryo development in sheep.
Recent information about Nerve growth factor (NGF), a protein traditionally associated to the nervous system that regulates survival and maturation of developing neurons, suggests that it may exertExpand
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CRISPR in livestock: From editing to printing
We present CRISPR applications to enhance livestock production in the context of a growing global demand of food, in terms of increasing efficiency. Expand
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Otoferlin gene editing in sheep via CRISPR-assisted ssODN-mediated Homology Directed Repair
Different mutations of the OTOF gene, encoding for otoferlin protein expressed in the cochlear inner hair cells, induces a form of deafness that is the major cause of nonsyndromic recessive auditoryExpand
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Cumulus cells during in vitro fertilization and oocyte vitrification in sheep: Remove, maintain or add?
The objective was to evaluate the developmental competence of immature and matured ovine oocytes after removing, maintaining or adding cumulus cells (CC) associated to vitrification by CryotopExpand
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Advances in the Generation of Genetically Modified (GM) Animal Models: Meeting report
The International Symposium and Course ‘‘Advances in the Generation of Genetically Modified (GM) Animal Models’’ was held in September 7–18, 2015, at the Institut Pasteur de Montevideo (IPMon),Expand