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Biochemical detection and monitoring of alcohol abuse and abstinence
  • P. C. Sharpe
  • Medicine
  • Annals of clinical biochemistry
  • 1 November 2001
None of the newer markers offers significant advantage, although CDT seems to be better at monitoring patients for increased alcohol consumption or progress towards abstinence, although GGT continues to remain the test that combines greatest convenience and sensitivity. Expand
Amyloid peptides and proteins in review.
A great deal of current knowledge is summarized on the occurrence, structure, folding pathways, chemistry and biology associated with amyloidogenic peptides and proteins and highlights some key factors that have been found to influence amyloidsogenesis. Expand
Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors.
Detailed investigations of the thiosemicarbazone group of ligands have demonstrated that they are highly effective chelators that, besides RR, also target a range of other molecules including NDRG1 and top2α, all of which contribute to their anticancer effects. Expand
Iron chelators of the dipyridylketone thiosemicarbazone class: precomplexation and transmetalation effects on anticancer activity.
The divalent Mn(II), Ni, Cu, and Zn(II) complexes of the HDpT analogues are equally active in preventing proliferation as their ligands, suggesting the complexes act as lipophilic vehicles facilitating intracellular delivery of the free ligand upon metal dissociation. Expand
Mean platelet volume in diabetes mellitus.
Since platelet size is a determinant of platelet function, with larger platelets being more reactive per unit volume, it is believed platelets may play a part in the micro- and macro-vascular complications of diabetes mellitus. Expand
Dipyridyl thiosemicarbazone chelators with potent and selective antitumor activity form iron complexes with redox activity.
The most effective HDpT ligands as antiproliferative agents possess considerable lipophilicity and were shown to be charge neutral at physiological pH, allowing access to intracellular Fe pools. Expand
2-Acetylpyridine thiosemicarbazones are potent iron chelators and antiproliferative agents: redox activity, iron complexation and characterization of their antitumor activity.
This investigation generated the related 2-acetylpyridine thiosemicarbazone (HApT) analogues to examine the influence of the methyl group at the imine carbon and identified structural features necessary to form Fe complexes with potent anticancer activity. Expand
Novel thiosemicarbazones of the ApT and DpT series and their copper complexes: identification of pronounced redox activity and characterization of their antitumor activity.
The structure-activity relationships described are important for the design of potent thiosemicarbazone Cu complexes and the importance of the inductive effects of substituents on the carbonyl group of the parent ketone, which influence the Cu(II/I) redox potentials because of their proximity to the metal center. Expand
Increase in mean platelet volume in patients with chronic renal failure treated with erythropoietin.
The results suggest that r-HuEPO affects thrombopoiesis and may be part of a group of humoral factors contributing to megakaryocyte development and maturation and may contribute to the increased risk ofThrombosis associated with r- HuEPO. Expand
Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous
It was demonstrated by EPR spectroscopy that dimeric copper compounds of the type [CuLCl](2), identified crystallographically, dissociate in solution to give monomeric 1:1 Cu:ligand complexes, which represent the biologically active form of the complex. Expand