• Publications
  • Influence
Process Control
Process Control System has evolved from isolated networks based on proprietary technologies to “OPEN” standardsbased networks connected to the rest of the enterprise. Expand
  • 155
  • 10
  • PDF
Modeling of Axial‐Flow Hollow Fiber Cell Culture Bioreactors
A review of the mathematical modeling of axial‐flow hollow fiber cell bioreactors is presented. The models cover the range of diffusion‐limited to convective‐flow dominant nutrient transportExpand
  • 62
  • 5
Process Control: A First Course with MATLAB
We will learn how to identify input and output variables, how to distinguish the manipulated variables, measured variables, and measured variables; they will be used to identify the control algorithm. Expand
  • 46
  • 4
  • PDF
Serum‐free media in hybridoma culture and monoclonal antibody production
The replacement of serum in hybridoma cultures is considered. The focus is on the effects of serum‐free media on hybridoma growth and monoclonal antibody secretion. Comparative literature data withExpand
  • 118
  • 3
Hollow-fiber bioreactors for mammalian cell culture.
  • 19
  • 3
Hybridoma growth and antibody secretion in serum-supplemented and low protein serum-free media.
Hybridoma cell growth and monoclonal antibody secretion were studied with three murine hybridomas, SS1.1, NS6.3 and 455, propagated in four low protein serum-free media and various serum-supplementedExpand
  • 27
  • 1
Transition probability cell cycle model. Part I--Balanced growth.
A cell cycle model based on the concept of a transition probability first proposed by Smith & Martin has been implemented as a differential equation model. The probabilistic A-state is modeled as aExpand
  • 27
  • 1
Transition probability cell cycle model. Part II--Non-balanced growth.
A cell cycle model based on the transition probability model of Smith & Martin has been extended to non-balanced growth conditions in batch cultures. The model considers transition to a quiescentExpand
  • 13
  • 1
Evaluation of immunocytochemical detection methods of incorporated bromodeoxyuridine in hybridomas.
Bivariate distributions obtained from nominal acid hydrolysis or thermal treatment methods used in the cell cycle analysis of incorporated bromodeoxyuridine were shown to be unacceptable withExpand
  • 9
  • 1
Modeling analysis of an intercalated‐spiral alternate‐dead‐ended hollow fiber bioreactor for mammalian cell cultures
The model analysis of a bioreactor with two intercalated‐spiral sets of hollow fibers with alternated dead ends is presented. Design equations are derived based on a model with two jumped fibers andExpand
  • 16
  • 1