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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
TLDR
This study has demonstrated that careful use of a shared control group represents a safe and effective approach to GWA analyses of multiple disease phenotypes; generated a genome-wide genotype database for future studies of common diseases in the British population; and shown that, provided individuals with non-European ancestry are excluded, the extent of population stratification in theBritish population is generally modest.
Genome-wide association study identifies eight loci associated with blood pressure
Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We
Identification of seven loci affecting mean telomere length and their association with disease
TLDR
A genome-wide meta-analysis of 37,684 individuals with replication of selected variants in an additional 10,739 individuals supports a causal role of telomere-length variation in some age-related diseases.
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
TLDR
These findings, enabled in part by increased statistical power resulting from the expansion of the control reference group to include individuals from the other disease groups, highlight notable new possibilities for autoimmune regulation and suggest that IL23R may be a common susceptibility factor for the major 'seronegative' diseases.
Extending the simple linear regression model to account for correlated responses: an introduction to generalized estimating equations and multi-level mixed modelling.
TLDR
The paper takes the reader through the relevant practicalities of model fitting, interpretation and criticism and demonstrates that, in a simple case such as this, analyses based upon these model-based approaches produce reassuringly similar inferences to standard analysesbased upon more conventional methods.
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls
TLDR
A large, direct genome-wide study of association between CNVs and eight common human diseases concludes that common CNVs that can be typed on existing platforms are unlikely to contribute greatly to the genetic basis ofcommon human diseases.
Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk
TLDR
A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function, and these findings suggest potential novel therapeutic pathways for cardiovascular disease prevention.
Genome-wide association study identifies five loci associated with lung function
TLDR
Genome-wide association with forced expiratory volume in 1 s (FEV1) and the ratio of FEV1 to forced vital capacity (FVC) in the SpiroMeta consortium offers mechanistic insight into pulmonary function regulation and indicate potential targets for interventions to alleviate respiratory disease.
Adjusting for treatment effects in studies of quantitative traits: antihypertensive therapy and systolic blood pressure
TLDR
Two of the adjustment methods based on a censored normal regression model appear to perform well across a range of realistic settings and there is no argument for undertaking a flawed analysis that wastes power and results in excessive bias.
Antepartum risk factors for newborn encephalopathy: the Western Australian case-control study
TLDR
The causes of newborn encephalopathy are heterogeneous and many of the causal pathways start before birth, including maternal thyroid disease, severe pre-eclampsia, and infertility treatment.
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