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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
There is increasing evidence that genome-wide association (GWA) studies represent a powerful approach to the identification of genes involved in common human diseases. We describe a joint GWA study… Expand
Identification of seven loci affecting mean telomere length and their association with disease
Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer and several age-associated diseases. We report here a genome-wide meta-analysis of 37,684 individuals with… Expand
Genome-wide association study identifies eight loci associated with blood pressure
Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We… Expand
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
We have genotyped 14,436 nonsynonymous SNPs (nsSNPs) and 897 major histocompatibility complex (MHC) tag SNPs from 1,000 independent cases of ankylosing spondylitis (AS), autoimmune thyroid disease… Expand
Extending the simple linear regression model to account for correlated responses: an introduction to generalized estimating equations and multi-level mixed modelling.
Much of the research in epidemiology and clinical science is based upon longitudinal designs which involve repeated measurements of a variable of interest in each of a series of individuals. Such… Expand
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls
Copy number variants (CNVs) account for a major proportion of human genetic polymorphism and have been predicted to have an important role in genetic susceptibility to common disease. To address this… Expand
How vague is vague? A simulation study of the impact of the use of vague prior distributions in MCMC using WinBUGS.
- P. Lambert, A. Sutton, P. Burton, K. Abrams, D. Jones
- Mathematics, Medicine
- Statistics in medicine
- 15 August 2005
There has been a recent growth in the use of Bayesian methods in medical research. The main reasons for this are the development of computer intensive simulation based methods such as Markov chain… Expand
Genome-wide association study identifies five loci associated with lung function
Pulmonary function measures are heritable traits that predict morbidity and mortality and define chronic obstructive pulmonary disease (COPD). We tested genome-wide association with forced expiratory… Expand
Antepartum risk factors for newborn encephalopathy: the Western Australian case-control study
Objective: To ascertain antepartum predictors of newborn encephalopathy in term infants. Design: Population based, unmatched case-control study. Setting: Metropolitan area of Western Australia, June… Expand
Adjusting for treatment effects in studies of quantitative traits: antihypertensive therapy and systolic blood pressure.
A population-based study of a quantitative trait may be seriously compromised when the trait is subject to the effects of a treatment. For example, in a typical study of quantitative blood pressure… Expand