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- Publications
- Influence
Differential role of extracellular histidines in copper, zinc, magnesium and proton modulation of the P2X7 purinergic receptor
- C. Acuña-Castillo, Claudio Coddou, P. Bull, J. Brito, J. Huidobro‐Toro
- Chemistry, Medicine
- Journal of neurochemistry
- 17 November 2006
The P2X7 receptor is a non‐selective cationic channel activated by extracellular ATP, belonging to the P2X receptor family. To assess the role of extracellular histidines on the allosteric modulation… Expand
Dissecting the Facilitator and Inhibitor Allosteric Metal Sites of the P2X4 Receptor Channel
- Claudio Coddou, C. Acuña-Castillo, P. Bull, J. Huidobro‐Toro
- Chemistry, Medicine
- Journal of Biological Chemistry
- 21 December 2007
Zinc and copper are atypical modulators of ligand-gated ionic channels in the central nervous system. We sought to identify the amino acids of the rat P2X4 receptor involved in trace metal… Expand
RelB, a new Rel family transcription activator that can interact with p50-NF-kappa B.
- R. Ryseck, P. Bull, +4 authors R. Bravo
- Biology, Medicine
- Molecular and cellular biology
- 1 February 1992
We have identified a serum-inducible gene, relB, which encodes a protein of 558 amino acids containing a region with high similarity to c-Rel and other members of the Rel family. Transcriptional… Expand
The xylanolytic enzyme system from the genus Penicillium.
- Renato Chávez, P. Bull, J. Eyzaguirre
- Biology, Medicine
- Journal of biotechnology
- 10 June 2006
In nature, there are numerous microorganisms that efficiently degrade xylan, a major component of lignocellulose. In particular, filamentous fungi have demonstrated a great capability for secreting a… Expand
Histidine 140 Plays a Key Role in the Inhibitory Modulation of the P2X4 Nucleotide Receptor by Copper but Not Zinc*
- Claudio Coddou, B. Morales, +5 authors J. Huidobro‐Toro
- Medicine, Biology
- Journal of Biological Chemistry
- 19 September 2003
To elucidate the role of extracellular histidines in the modulation of the rat P2X4 receptor by trace metals, we generated single, double, and triple histidine mutants for residues 140, 241, and 286,… Expand
Extracellular histidine residues identify common structural determinants in the copper/zinc P2X2 receptor modulation
- Ramón A. Lorca, Claudio Coddou, M. C. Gazitúa, P. Bull, Cristián Arredondo, J. Huidobro‐Toro
- Chemistry, Medicine
- Journal of neurochemistry
- 1 October 2005
To assess the mechanism of P2X2 receptor modulation by transition metals, the cDNA for the wild‐type receptor was injected to Xenopus laevis oocytes and examined 48–72 h later by the two‐electrode… Expand
Differences in expression of two endoxylanase genes (xynA and xynB) from Penicillium purpurogenum.
- R. Chávez, K. Schachter, +4 authors J. Eyzaguirre
- Biology, Medicine
- Gene
- 26 June 2002
A number of xylanolytic microorganisms secrete to the medium several molecular forms of endoxylanases. The physiological function of these isoforms is not clear; one possibility is that they are… Expand
Galectin-8 binds specific beta1 integrins and induces polarized spreading highlighted by asymmetric lamellipodia in Jurkat T cells.
- Claudia B. Cárcamo, E. Pardo, +8 authors A. Soza
- Biology, Medicine
- Experimental cell research
- 15 February 2006
Integrin-mediated encounters of T cells with extracellular cues lead these cells to adhere to a variety of substrates and acquire a spread phenotype needed for their tissue incursions. We studied the… Expand
4‐Bromo‐2,5‐dimethoxyphenethylamine (2C‐B) and structurally related phenylethylamines are potent 5‐HT2A receptor antagonists in Xenopus laevis oocytes
- Claudio Villalobos, P. Bull, P. Sáez, B. Cassels, J. Huidobro-Toro
- Biology, Medicine
- British journal of pharmacology
- 1 April 2004
We recently described that several 2‐(2,5‐dimethoxy‐4‐substituted phenyl)ethylamines (PEAs), including 4‐I=2C‐I, 4‐Br=2C‐B, and 4‐CH3=2C‐D analogs, are partial agonists at 5‐HT2C receptors, and show… Expand
Reactive Oxygen Species Potentiate the P2X2 Receptor Activity through Intracellular Cys430
- Claudio Coddou, J. Codocedo, +5 authors J. Huidobro‐Toro
- Chemistry, Medicine
- The Journal of Neuroscience
- 30 September 2009
P2X receptor channels (P2XRs) are allosterically modulated by several compounds, mainly acting at the ectodomain of the receptor. Like copper, mercury, a metal that induces oxidative stress in cells,… Expand
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