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Differential role of extracellular histidines in copper, zinc, magnesium and proton modulation of the P2X7 purinergic receptor
The P2X7 receptor is a non‐selective cationic channel activated by extracellular ATP, belonging to the P2X receptor family. To assess the role of extracellular histidines on the allosteric modulationExpand
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Dissecting the Facilitator and Inhibitor Allosteric Metal Sites of the P2X4 Receptor Channel
Zinc and copper are atypical modulators of ligand-gated ionic channels in the central nervous system. We sought to identify the amino acids of the rat P2X4 receptor involved in trace metalExpand
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RelB, a new Rel family transcription activator that can interact with p50-NF-kappa B.
We have identified a serum-inducible gene, relB, which encodes a protein of 558 amino acids containing a region with high similarity to c-Rel and other members of the Rel family. TranscriptionalExpand
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The xylanolytic enzyme system from the genus Penicillium.
In nature, there are numerous microorganisms that efficiently degrade xylan, a major component of lignocellulose. In particular, filamentous fungi have demonstrated a great capability for secreting aExpand
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Histidine 140 Plays a Key Role in the Inhibitory Modulation of the P2X4 Nucleotide Receptor by Copper but Not Zinc*
To elucidate the role of extracellular histidines in the modulation of the rat P2X4 receptor by trace metals, we generated single, double, and triple histidine mutants for residues 140, 241, and 286,Expand
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Extracellular histidine residues identify common structural determinants in the copper/zinc P2X2 receptor modulation
To assess the mechanism of P2X2 receptor modulation by transition metals, the cDNA for the wild‐type receptor was injected to Xenopus laevis oocytes and examined 48–72 h later by the two‐electrodeExpand
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Differences in expression of two endoxylanase genes (xynA and xynB) from Penicillium purpurogenum.
A number of xylanolytic microorganisms secrete to the medium several molecular forms of endoxylanases. The physiological function of these isoforms is not clear; one possibility is that they areExpand
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Galectin-8 binds specific beta1 integrins and induces polarized spreading highlighted by asymmetric lamellipodia in Jurkat T cells.
Integrin-mediated encounters of T cells with extracellular cues lead these cells to adhere to a variety of substrates and acquire a spread phenotype needed for their tissue incursions. We studied theExpand
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4‐Bromo‐2,5‐dimethoxyphenethylamine (2C‐B) and structurally related phenylethylamines are potent 5‐HT2A receptor antagonists in Xenopus laevis oocytes
We recently described that several 2‐(2,5‐dimethoxy‐4‐substituted phenyl)ethylamines (PEAs), including 4‐I=2C‐I, 4‐Br=2C‐B, and 4‐CH3=2C‐D analogs, are partial agonists at 5‐HT2C receptors, and showExpand
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Reactive Oxygen Species Potentiate the P2X2 Receptor Activity through Intracellular Cys430
P2X receptor channels (P2XRs) are allosterically modulated by several compounds, mainly acting at the ectodomain of the receptor. Like copper, mercury, a metal that induces oxidative stress in cells,Expand
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