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  • Fadlo R. Khuri, John Nemunaitis, +13 authors David H. Kirn
  • Medicine
  • Nature Medicine
  • 2000 (First Published: 1 August 2000)
  • ONYX-015 is an adenovirus with the E1B 55-kDa gene deleted, engineered to selectively replicate in and lyse p53-deficient cancer cells while sparing normal cells. Although ONYX-015 and chemotherapyContinue Reading
  • Gary L Clayman, Adel K. El-Naggar, +11 authors Helmuth Goepfert
  • Medicine
  • Journal of clinical oncology : official journal…
  • 1998 (First Published: 1 June 1998)
  • PURPOSE Standard therapies of head and neck squamous cell carcinoma (HNSCC) often cause profound morbidity and have not significantly improved survival over the last 30 years. Preclinical studiesContinue Reading