P. Brown

Publications455
h-index99
Citations34,367
Highly Influential Citations1,986
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Dopamine Dependency of Oscillations between Subthalamic Nucleus and Pallidum in Parkinson's Disease
TLDR
Local potentials from the globus pallidus interna and subthalamic nucleus are recorded in four awake patients after neurosurgery for Parkinson's disease to demonstrate synchronization of activity does occur between pallidum and STN, and its pattern is critically dependent on the level of dopaminergic activity.
Pathological synchronization in Parkinson's disease: networks, models and treatments
Oscillatory nature of human basal ganglia activity: Relationship to the pathophysiology of Parkinson's disease
  • P. Brown
  • Biology, Psychology
    Movement disorders : official journal of the…
  • 1 April 2003
TLDR
It is argued that the balance between these modes determines the effects of basal ganglia‐thalamocortical projections on the motor areas of the cortex, and that synchronisation at high frequency restores dynamic task‐related cortical ensemble activity in the gamma band.
Adaptive Deep Brain Stimulation In Advanced Parkinson Disease
TLDR
This work uses a BCI to interpret pathological brain activity in patients with advanced Parkinson disease and to use this feedback to control when therapeutic deep brain stimulation (DBS) is delivered to improve on both the efficacy and efficiency of conventional continuous DBS.
Postural electromyographic responses in the arm and leg following galvanic vestibular stimulation in man
TLDR
The difference in latency between the onset of the early component of the response in arm and leg muscles suggests that this part of the responded uses a descending pathway which conducts impulses down the spinal cord with a velocity comparable with that of the fast conducting component ofThe corticospinal tract.
Parkinsonian Beta Oscillations in the External Globus Pallidus and Their Relationship with Subthalamic Nucleus Activity
TLDR
It is proposed that GP neurons, by virtue of their spatiotemporal synchronization, widespread axon collaterals and feed-back/feed-forward mechanisms, are well placed to orchestrate and propagate exaggerated β oscillations throughout the entire basal ganglia in PD.
Disrupted Dopamine Transmission and the Emergence of Exaggerated Beta Oscillations in Subthalamic Nucleus and Cerebral Cortex
TLDR
It is demonstrated that beta oscillations are inappropriately exaggerated, compared with controls, in a brain-state-dependent manner after chronic dopamine loss, and targeting the plastic processes underlying the delayed emergence of pathological Beta oscillations after continuing dopaminergic dysfunction may offer considerable therapeutic promise.
Movement-related changes in synchronization in the human basal ganglia.
TLDR
Movement-related frequency-specific changes in synchronization occur in the basal ganglia and extend to involve subcortico-cortical motor loops in the frequency domain, which might provide a means for temporal co-ordination within and across different processing streams in thebasal ganglia.
High-Frequency Stimulation of the Subthalamic Nucleus Suppresses Oscillatory β Activity in Patients with Parkinson's Disease in Parallel with Improvement in Motor Performance
TLDR
The findings suggest that HFS may act by modulating pathological patterns of synchronized oscillations, specifically by reduction of pathological β activity in PD.
Reduction in subthalamic 8–35 Hz oscillatory activity correlates with clinical improvement in Parkinson's disease
TLDR
A link between levodopa‐induced improvements in bradykinesia and rigidity and reductions in population synchrony at frequencies < 35 Hz in the region of the STN in patients with PD is supported.
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