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Dopamine Dependency of Oscillations between Subthalamic Nucleus and Pallidum in Parkinson's Disease
The extent of synchronization within and between the nuclei of the basal ganglia is unknown in Parkinson's disease. The question is an important one because synchronization will increase postsynapticExpand
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Pathological synchronization in Parkinson's disease: networks, models and treatments
Parkinson's disease is a common and disabling disorder of movement owing to dopaminergic denervation of the striatum. However, it is still unclear how this denervation perverts normal functioning toExpand
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Oscillatory nature of human basal ganglia activity: Relationship to the pathophysiology of Parkinson's disease
  • P. Brown
  • Biology, Medicine
  • Movement disorders : official journal of the…
  • 1 April 2003
Alterations of basal ganglia physiology in parkinsonism may consist of two elements, an increase in the firing rate of neurones and a change in the pattern of synchronisation of discharges betweenExpand
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Postural electromyographic responses in the arm and leg following galvanic vestibular stimulation in man
Application of a small (around 1 mA), constant electric current between the mastoid processes (galvanic stimulation) of a standing subject produces enhanced body sway in the approximate direction ofExpand
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Adaptive Deep Brain Stimulation In Advanced Parkinson Disease
Brain–computer interfaces (BCIs) could potentially be used to interact with pathological brain signals to intervene and ameliorate their effects in disease states. Here, we provide proof‐of‐principleExpand
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Parkinsonian Beta Oscillations in the External Globus Pallidus and Their Relationship with Subthalamic Nucleus Activity
Inappropriately synchronized beta (β) oscillations (15–30 Hz) in the subthalamic nucleus (STN) accompany movement difficulties in idiopathic Parkinson's disease (PD). The cellular and networkExpand
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Disrupted Dopamine Transmission and the Emergence of Exaggerated Beta Oscillations in Subthalamic Nucleus and Cerebral Cortex
In the subthalamic nucleus (STN) of Parkinson's disease (PD) patients, a pronounced synchronization of oscillatory activity at beta frequencies (15–30 Hz) accompanies movement difficulties. AbnormalExpand
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High-Frequency Stimulation of the Subthalamic Nucleus Suppresses Oscillatory β Activity in Patients with Parkinson's Disease in Parallel with Improvement in Motor Performance
High-frequency stimulation (HFS) of the subthalamic nucleus (STN) is a well-established therapy for patients with severe Parkinson's disease (PD), but its mechanism of action is unclear. ExaggeratedExpand
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Movement-related changes in synchronization in the human basal ganglia.
There is a wealth of data suggesting that behavioural events are reflected in the basal ganglia through phasic changes in the discharge of individual neurones. Here we investigate whether events areExpand
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Reduction in subthalamic 8–35 Hz oscillatory activity correlates with clinical improvement in Parkinson's disease
Strong synchronization of neuronal activity occurs in the 8–35 Hz band in the subthalamic nucleus (STN) of patients with Parkinson's disease (PD) and is evident as oscillatory local field potentialExpand
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