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Does colchicine work? The results of the first controlled study in acute gout.
TLDR
Two-thirds of colchicine-treated patients improved after 48 hours, but only one-third of the patients receiving placebo demonstrated similar improvement; significant differences from placebo were shown after 18-30 hours.
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Clinical Pharmacokinetics of the Salicylates
TLDR
Pharmacokinetic parameters in patients with rheumatoid arthritis, osteoarthritis, chronic renal failure or liver disease are essentially the same, and no significant differences exist between the pharmacokinetics of the salicylates in the elderly or in children when compared with young adults.
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Nonsteroidal antiinflammatory drugs--differences and similarities.
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Interpreting the clinical significance of the differential inhibition of cyclooxygenase-1 and cyclooxygenase-2.
TLDR
The International Consensus Meeting on the Mode of Action of COX-2 Inhibition (ICMMAC) brought together 17 international experts in arthritis, gastroenterology and pharmacology to foster a consensus definition on COx-2 specificity and to consider the clinical relevance of COZ-2-specific agents.
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Basic biology and clinical application of specific cyclooxygenase-2 inhibitors.
TLDR
Clinical trials demonstrate the potential for clinically meaningful reductions in the incidence of the most serious GI complications found with nonselective NSAIDs, i.e., ulcer, perforation, and GI bleeding.
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Circulating cytokine levels in patients with rheumatoid arthritis: results of a double blind trial with sulphasalazine.
TLDR
Results suggest that sulphasalazine may exert its disease modifying effect partly by suppressing cytokine production in vivo.
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Autologous hemopoietic stem cell transplantation in severe rheumatoid arthritis: a report from the EBMT and ABMTR.
TLDR
Autologous HSCT is a relatively safe form of salvage treatment in severe, resistant RA, and in these open label studies significant responses were achieved in most patients, with over 50% achieving an ACR 50 or more response at 12 months.
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A phase I/II dose escalation study of intensified cyclophosphamide and autologous blood stem cell rescue in severe, active rheumatoid arthritis.
TLDR
High-dose CYC and unmanipulated autologous blood stem cell rescue has acceptable dose-dependent toxicity in severe, treatment-resistant RA, and 200 mg/kg of CYC induces substantial clinical responses.
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A double blind, randomized, multicenter, parallel group study of the effectiveness and tolerance of intraarticular hyaluronan in osteoarthritis of the knee.
TLDR
Intraarticular HA treatment was significantly more effective than saline vehicle in mild to moderate OA of the knee for the 13 week postinjection period of the study.
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The Bone and Joint Decade: 2000‐2010
The United Nations has endorsed a Decade to focus attention on worldwide epidemic of musculoskeletal diseases.
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