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Microsomal reduction of 3-amino-1,2,4-benzotriazine 1,4-dioxide to a free radical.
The drug SR 4233 (3-amino-1,2,4-benzotriazine 1,4-dioxide) is under pharmacological study as the lead compound in a new series of hypoxia-activated drugs, the benzotriazine N-oxides. However, theExpand
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Efficient metal-ion catalyzed template-directed oligonucleotide synthesis.
The Pb2+ and Zn2+ ions are efficient catalysts for the polycytidylic acid-directed polymerization of an activated guanylic acid derivative, guanosine 5'-phosphorimidazolide. The products includeExpand
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Catalysis of accurate poly(C)-directed synthesis of 3'-5'-linked oligoguanylates by Zn2+.
Abstract Zn 2+ is an efficient catalyst for the oligomerization of guanosine 5′-phosphorimidazolide on a polycytidylic acid template. Up to 75% of the input ImpG † is converted to oligomers with aExpand
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Inactivation of aldophosphamide by human aldehyde dehydrogenase isozyme 3.
Tumors resistant to chemotherapeutic oxazaphosphorines such as cyclophosphamide often overexpress aldehyde dehydrogenase (ALDH), some isozymes of which catalyze the oxidization of aldophosphamide, anExpand
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Autotaxin structure-activity relationships revealed through lysophosphatidylcholine analogs.
Autotaxin (ATX) catalyzes the hydrolysis of lysophosphatidylcholine (LPC) to form the bioactive lipid lysophosphatidic acid (LPA). LPA stimulates cell proliferation, cell survival, and cell migrationExpand
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Reactions between ribonucleoside derivatives and formaldehyde in ethanol solution
2′,3′-O-Isopropylidene-adenosine, -cytidine, and -guanosine, (2a), (3a), and (4a), respectively react with formaldehyde in ethanol solution to give the corresponding N-ethoxymethyl derivatives, (2b),Expand
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Imidazodiazepinediones: a new class of adenosine receptor antagonists.
A series of imidazo[4,5-e][1-4]diazepine-5,8-diones were synthesized from hypoxanthines. Certain of these cyclic homologues of caffeine, theophylline, theobromine, 3-isobutyl-1-methylxanthine, andExpand
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1-Substituent Xanthines
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Preparation of Xanthine-3-Acetic Acid and Some Derivatives
Abstract A general procedure for the preparation of 3-alkyl-xanthines from 7-benzylxanthine is described and used for the synthesis of xanthine-3-acetic acid.
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