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Disability and T2 MRI lesions: a 20-year follow-up of patients with relapse onset of multiple sclerosis.
Clinically isolated syndromes (CIS), such as optic neuritis, brainstem or spinal cord syndromes are frequently the first clinical presentations of multiple sclerosis. However, not all CIS patientsExpand
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A longitudinal study of abnormalities on MRI and disability from multiple sclerosis.
BACKGROUND In patients with isolated syndromes that are clinically suggestive of multiple sclerosis, such as optic neuritis or brain-stem or spinal cord syndromes, the presence of lesions asExpand
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Detection of ventricular enlargement in patients at the earliest clinical stage of MS
Article abstract The aim of this study was to determine whether atrophy could be detected at the earliest clinical stages of MS. Patients were selected from a 1-year follow-up MRI study of clinicallyExpand
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Application of the new McDonald criteria to patients with clinically isolated syndromes suggestive of multiple sclerosis
Traditionally, multiple sclerosis (MS) has been diagnosed on the basis of clinical evidence of dissemination in time and space. Previously, it could not be diagnosed in patients with single clinicalExpand
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Recovery from optic neuritis is associated with a change in the distribution of cerebral response to visual stimulation: a functional magnetic resonance imaging study.
OBJECTIVES Recovery to normal or near normal visual acuity is usual after acute demyelinating optic neuritis, despite the frequent persistence of conduction abnormalities as evidenced by the visualExpand
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Interferon beta-1a in primary progressive MS: an exploratory, randomized, controlled trial.
BACKGROUND Patients with primary progressive MS have atypical clinical and MRI characteristics and have been excluded from most therapeutic trials. The authors report a randomized, controlled trialExpand
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Progressive ventricular enlargement in patients with clinically isolated syndromes is associated with the early development of multiple sclerosis
Background: In patients with clinically isolated syndromes (CIS) suggestive of multiple sclerosis (MS), the extent of brain magnetic resonance imaging (MRI) lesion load influences the probability andExpand
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Multisequence MRI in clinically isolated syndromes and the early development of MS
Objective: To apply multisequence MRI techniques to patients with clinically isolated syndromes, to document the pattern and frequency of abnormalities at baseline and early follow-up, and toExpand
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Lesion heterogeneity in multiple sclerosis: a study of the relations between appearances on T1 weighted images, T1 relaxation times, and metabolite concentrations
OBJECTIVES Multiple sclerosis lesions appear as areas of high signal on T2 weighted MRI. A proportion of these lesions, when viewed on T1 weighted MRI, appear hypointense compared with surroundingExpand
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Detection of optic nerve atrophy following a single episode of unilateral optic neuritis by MRI using a fat-saturated short-echo fast FLAIR sequence
Abstract We describe an MRI technique for quantifying optic nerve atrophy resulting from a single episode of unilateral optic neuritis. We imaged 17 patients, with a median time since onset of opticExpand
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