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Human gene expression first occurs between the four- and eight-cell stages of preimplantation development
Changes in the pattern of polypeptides synthesized during the pre-implantation stages of human development are described, and it is demonstrated that some of the major qualitative changes which occur between the four- and eight-cell stages are dependent on transcription.
The transition from maternal to embryonic control in the 2‐cell mouse embryo.
It is suggested that during the 2‐cell stage the embryonic genome shows transcriptional activity in two phases at 18‐21 and 26‐29 h post‐insemination, that these transcripts are utilized soon after their synthesis, and that most maternal transcripts used before the second phase of embryonic transcription become ineffective soon afterwards.
Conventional in-vitro fertilisation versus intracytoplasmic sperm injection for the treatment of non-male-factor infertility: a randomised controlled trial
The results support the current practice of reserving ICSI only for severe male-factor problems and offer no advantage over IVF in terms of clinical outcome in cases of non-male-factor infertility.
Transient cooling to room temperature can cause irreversible disruption of the meiotic spindle in the human oocyte.
The spindles in oocytes that were cooled for either 10 or 30 minutes and then allowed to recover at 37 degrees C for either 1 or 4 hours were found to resemble those in noncooled control oocytes in less than one half of the cases examined.
A prospective controlled study of the effect of intramural uterine fibroids on the outcome of assisted conception.
It is demonstrated that an intramural fibroid halves the chances of an ongoing pregnancy following assisted conception.
Preimplantation genetic diagnosis
PGD has provided unique insights into aspects of reproductive genetics and early human development, but has also raised important new ethical issues about assisted human reproduction.
Proof of principle and first cases using preimplantation genetic haplotyping--a paradigm shift for embryo diagnosis.
PGH represents a paradigm shift in embryo diagnosis, as one panel of markers can be used for all carriers of the same monogenic disease, bypassing the need for development of mutation-specific tests, and widening the scope and availability of preimplantation genetic testing.
Natural killer cells, miscarriage, and infertility
Enthusiasm for new treatments aimed at natural killer cells in women with reproductive failure is unfortunately not backed up by the science
Influence of past reproductive performance on risk of spontaneous abortion.
A knowledge of the patient's reproductive history is essential for the clinical assessment of her risk of spontaneous abortion, as the most important predictive factor for spontaneous abortion is a previous abortion.
A systematic review of the effect of oral antioxidants on male infertility.
A systematic review of randomized studies to evaluate the effects of oral antioxidants on sperm quality and pregnancy rate in infertile men found 14 of the 17 trials showed an improvement in either sperm quality or pregnancy rate after antioxidant therapy.