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Homer: a protein that selectively binds metabotropic glutamate receptors
Spatial localization and clustering of membrane proteins is critical to neuronal development and synaptic plasticity. Recent studies have identified a family of proteins, the PDZ proteins, thatExpand
Coupling of mGluR/Homer and PSD-95 Complexes by the Shank Family of Postsynaptic Density Proteins
Shank is a recently described family of postsynaptic proteins that function as part of the NMDA receptor-associated PSD-95 complex (Naisbitt et al., 1999 [this issue of Neuron]). Here, we report thatExpand
Preso1 dynamically regulates group I metabotropic glutamate receptors
Group I metabotropic glutamate receptors (mGluRs), including mGluR1 and mGluR5, are G protein–coupled receptors (GPCRs) that are expressed at excitatory synapses in brain and spinal cord. GPCRs areExpand
Synaptotagmin-Like Proteins Control Formation of a Single Apical Membrane Domain in Epithelial Cells
The formation of epithelial tissues requires both the generation of apical–basal polarity and the coordination of this polarity between neighbouring cells to form a central lumen. During de novoExpand
Being Overweight Modifies the Association Between Cardiovascular Risk Factors and Microalbuminuria in Adolescents
OBJECTIVE. The goal was to determine the association between cardiovascular risk factors and microalbuminuria in a nationally representative sample of adolescents and to determine whether beingExpand
Magnetohydrodynamics of blood flow
The changes in hydrostatic pressure and electrical potentials across vessels in the human vasculature in the presence of a large static magnetic field are estimated to determine the feasibility of inExpand
De novo lumen formation and elongation in the developing nephron: a central role for afadin in apical polarity
A fundamental process in biology is the de novo formation and morphogenesis of polarized tubules. Although these processes are essential for the formation of multiple metazoan organ systems, littleExpand
Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity
In multicellular epithelial tissues, the orientation of polarity of each cell must be coordinated. Previously, we reported that for Madin–Darby canine kidney cells in three‐dimensional collagen gelExpand
p120 catenin is required for normal renal tubulogenesis and glomerulogenesis
Defects in the development or maintenance of tubule diameter correlate with polycystic kidney disease. Here, we report that absence of the cadherin regulator p120 catenin (p120ctn) from the renalExpand
Transient Hyperglycemia Affects the Extent of Ischemia-Reperfusion-induced Renal Injury in Rats
Background:Chronic hyperglycemia is known to increase renal injury, particularly during ischemia-reperfusion episodes. The goal of this study was to examine whether transient hyperglycemia during orExpand